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Big Endothelin1 Fragment 2238 Human CAS 124932612 China Suppliers Factory
High-purity Big Endothelin-1 Fragment 22-38 human CAS 124932-61-2 from leading China suppliers. Our factory provides GMP-compliant synthetic peptides for ECE enzyme research and cardiovascular studies.
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
Big Endothelin-1 Fragment (22-38) (human), identified by CAS NO.124932-61-2, is a high-purity synthetic peptide designed as a substrate analog for the endothelin-converting enzyme (ECE). By mimicking the natural C-terminal region of the precursor, this fragment serves as a critical biochemical tool for investigating the enzymatic cleavage mechanisms that regulate the maturation of Big ET-1 into active Endothelin-1 (ET-1), which is pivotal for controlling vascular tone and tissue remodeling.
Engineered for high-precision research, this peptide is indispensable for scientists specializing in cardiovascular pathophysiology. It provides essential insights into the mechanisms underlying hypertension, pulmonary arterial hypertension, and heart failure. By utilizing this fragment as a reference standard, researchers can effectively validate ECE activity and screen for potential enzyme inhibitors, facilitating the development of novel pharmacological interventions for endothelial dysfunction.
Detailed Parameters
| Product Name | Big Endothelin-1 Fragment (22-38) (human) | CAS NO. | 124932-61-2 |
|---|---|---|---|
| Appearance | White to off-white lyophilized powder | Molecular Formula | C₈₀H₁₂₅N₂₃O₂₅ |
| Molecular Weight | 1839.0g/mol | Purity (RP-HPLC) | ≥98% |
| Solubility | 1M acetic acid, DMSO, or deionized water | Endotoxin | ≤1 EU/mg |
| Storage Conditions | Store at -20°C, protected from light/moisture | MOQ | 1g |
Key Advantages
Ultra-High Purity
Ensured purity of ≥98% via RP-HPLC, minimizing experimental variability and ensuring reproducible research outcomes.
Rapid USA Shipping
Strategically stocked in USA warehouses to ensure the fastest possible delivery and reduced transit times for local labs.
GMP Compliance
Produced in GMP-compliant systems with standardized quality control from raw material to final packaging.
Proven Bio-Activity
Validated as an effective substrate analog for ECE, facilitating accurate modeling of endothelial dysfunction.
Complete Documentation
Each batch includes a COA, HPLC purity report, and MS chromatograms for full traceability and transparency.
Low Endotoxin
Strictly controlled endotoxin levels (≤1 EU/mg), making it suitable for sensitive in vitro and ex vivo applications.
Product Gallery
Management Platforms
Batch Traceability
Full lifecycle tracking from raw material procurement through synthesis to final shipping.
GMP Production
Rigorous adherence to Good Manufacturing Practices to ensure pharmacological grade stability.
Quality Validation
Professional laboratory testing including mass spectrometry and HPLC for every single batch.
Cold Chain Logistics
Specialized packaging solutions to maintain stability and integrity during international air freight.
Flexible Scaling
Capable of supplying research needs from gram-level samples to ton-level industrial production.
Regulatory Support
Full compliance with international trade standards and provision of DMF/FDA certified source materials.
Investment Return Comparison
| Evaluation Metric | Standard Grade Peptides | GlobalTech Premium Grade |
|---|---|---|
| Purity Consistency | Variable (90-95%) | Ultra-Stable (≥98%) |
| Delivery Lead Time | 2-4 Weeks | 3-7 Days (USA Stock) |
| Documentation | Basic COA only | Full COA + HPLC + MS |
| Endotoxin Level | Unspecified | Guaranteed ≤1 EU/mg |
| Research Reliability | Moderate Risk | High Precision Standard |
Frequently Asked Questions
Q: What is the primary application of Big Endothelin-1 Fragment (22-38)?
It is primarily used as a substrate analog for the endothelin-converting enzyme (ECE) to study the biosynthesis of ET-1 and its role in cardiovascular diseases like hypertension.
Q: How should this peptide be stored to maintain stability?
The product should be stored at -20°C and must be protected from light and moisture to prevent degradation.
Q: In what solvents is Big Endothelin-1 Fragment (22-38) soluble?
It is soluble in 1M acetic acid, DMSO, or deionized water, allowing for flexible preparation in various experimental buffers.
Q: Do you provide third-party testing reports for your pharmaceutical intermediates?
Yes, in addition to our internal COA and HPLC reports, third-party testing reports are available upon request to ensure absolute transparency.
Q: What is the typical lead time for shipping from the USA stock?
Orders fulfilled from our USA stock are typically processed and shipped via DHL/FedEx/UPS, reaching most domestic locations within a few business days.
Q: Is this product intended for clinical or human use?
No, this product is strictly intended for in vitro and ex vivo research applications and is not for clinical or diagnostic use in humans.
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