Ghrelin (human) CAS NO.258279-04-8

Ghrelin (human) (CAS NO. 258279-04-8) is a 28-amino-acid peptide hormone with the molecular formula C₁₄₉H₂₄₉N₄₇O₄₂ and molecular weight 3370.9 g/mol. As the only known endogenous ligand of the growth hormone secretagogue receptor 1a (GHS-R1a), it is a key regulator of appetite, growth hormone (GH) secretion, and energy metabolism, making it indispensable for endocrinology, metabolism, and obesity research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ghrelin (human)
CAS NO.	258279-04-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₉H₂₄₉N₄₇O₄₂
Molecular Weight	3370.9 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous ligand of the growth hormone secretagogue receptor 1a (GHS-R1a; human, Ki: 0.1–1 nM). Stimulates growth hormone (GH) release from the pituitary, increases appetite via hypothalamic NPY/AgRP pathway activation, and modulates energy metabolism, stress responses, and gut motility. O-acyl modification (e.g., octanoylation at Ser³) is critical for activity.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHS-R1a Activation: Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) with high affinity (human, Ki: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.

Appetite Stimulation: Crosses the blood-brain barrier to activate hypothalamic orexigenic neurons (NPY/AgRP pathway), increasing hunger and food intake.

GH Secretion: Stimulates growth hormone release from the anterior pituitary gland via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation.

Metabolic Regulation: Modulates energy balance by promoting adipogenesis, reducing fat oxidation, and influencing glucose metabolism.

2.PRODUCT INDICATIONS

Appetite & Obesity Research: Studying hyperphagia, satiety regulation, and metabolic disorders (e.g., obesity, cachexia).

Endocrine Studies: Investigating GH deficiency, acromegaly, and age-related hormonal changes.

Preclinical Drug Development: Screening GHS-R1a agonists/antagonists for treating eating disorders, growth disorders, or metabolic diseases.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Validation:

Increases food intake by 40–60% in fasted rodent models (ED₅₀: 0.3 nM).

Stimulates GH release by 3–5x in human pituitary cell cultures (concentration: 1 nM).

Promotes weight gain in cachectic animal models (20–30% increase over controls).

Therapeutic Potential: GHS-R1a antagonists derived from ghrelin are in clinical trials for obesity, while agonists show promise for GH deficiency therapy.

4.DELIVERY & SHIPPING

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