GHRF, rat

GHRF, rat (Growth Hormone-Releasing Factor, rat) is a high-purity synthetic peptide corresponding to the 44-amino acid sequence of rat growth hormone-releasing hormone (GHRH). This bioactive peptide functions as a potent and specific agonist for GHRH receptors, stimulating growth hormone secretion from pituitary somatotrophs. With HPLC-verified purity and comprehensive analytical documentation, it provides researche…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GHRF, rat (Growth Hormone-Releasing Factor, rat)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C225H361N77O66S
Molecular Weight	5232.93 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), DMSO; may require gentle vortexing
Endotoxin	< 1.0 EU/mg
Biological Activity	Growth hormone-releasing hormone (GHRH) analog; stimulates growth hormone secretion from pituitary somatotrophs via GHRH receptor activation.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHRF, rat binds with high affinity to GHRH receptors on pituitary somatotroph cells, activating G-protein coupled signaling pathways. This binding stimulates adenylate cyclase activity, increasing intracellular cAMP levels and activating protein kinase A (PKA). The downstream effects include phosphorylation of transcription factors (such as CREB), enhanced growth hormone gene expression, and stimulation of growth hormone synthesis and secretion. The peptide exhibits species specificity for rat GHRH receptors, making it particularly valuable for rat-based research models of growth and endocrine function.

2.PRODUCT INDICATIONS

Endocrine Research: Investigation of growth hormone regulation, pituitary function, and growth axis signaling

Metabolic Studies: Research on growth hormone's role in metabolism, body composition, and energy homeostasis

Animal Model Development: Use in rat models of growth hormone deficiency, dwarfism, and metabolic disorders

Drug Discovery: Screening for GHRH receptor agonists or antagonists for therapeutic applications

Receptor Pharmacology: Study of GHRH receptor binding, signal transduction, and receptor subtype specificity

Preclinical Studies: Evaluation of growth-promoting effects and endocrine system modulation

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated potent stimulation of growth hormone secretion in rat pituitary cells and in vivo models

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation

Species Specificity: Optimized for rat GHRH receptors, ensuring reliable results in rat-based research

Research Reproducibility: Consistent performance in growth hormone release assays, receptor binding studies, and animal experiments

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications

Translational Relevance: Supports preclinical research on growth disorders, metabolic diseases, and endocrine therapeutics

Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.