GHRP-2

GHRP-2 (Growth Hormone-Releasing Peptide-2) is a synthetic hexapeptide (D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH₂) belonging to the growth hormone secretagogue (GHS) family. As a potent, metabolically stable agonist of the ghrelin receptor (GHSR-1a), it powerfully stimulates the pulsatile release of endogenous growth hormone (GH) from the anterior pituitary, bypassing the hypothalamic GHRH pathway.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GHRP - 2 (Growth Hormone - Releasing Peptide - 2
CAS NO.	/
Appearance	White to off - white lyophilized powder
Molecular Formula	C45H54O6N9
Molecular Weight	818g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, and DMSO
Endotoxin	≤5.0 EU/mg
Biological Activity	A potent agonist of the ghrelin receptor (GHSR - 1a)
Storage Conditions	Store at - 20°C to - 80°C in a sealed, desiccated container, protected from moisture and light.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHRP-2 exerts its primary effects by binding to and activating the Growth Hormone Secretagogue Receptor 1a (GHSR-1a), also known as the ghrelin receptor, on pituitary somatotrophs and hypothalamic neurons. This is a Gq/11-protein coupled receptor. Activation leads to phospholipase C (PLC) stimulation, inositol trisphosphate (IP₃) and diacylglycerol (DAG) generation, intracellular calcium mobilization, and protein kinase C (PKC) activation.

2.PRODUCT INDICATIONS

Endocrinology & Physiology Research: Investigating the regulation of GH secretion, the GHSR-1a pathway, and the synergistic effects with GHRH.
Metabolism & Body Composition Studies: Exploring the effects of stimulated GH on lipolysis, protein synthesis, glucose metabolism, and muscle growth in animal models.
Aging Research: Studying GH axis function in models of age-related somatopause.
Peptide Pharmacology: Serving as a reference standard GHSR-1a agonist for screening antagonists or comparing the efficacy of new growth hormone secretagogues.
HPA Axis Studies: Researching the mechanism of GHSR-1a-mediated stimulation of ACTH and cortisol release.
Performance & Recovery Models: Used in preclinical models to study the effects of elevated GH on physical performance, wound healing, and tissue repair.

3.CLINICAL EFFICACY OF PRODUCT

Established Potency: It is one of the most potent synthetic GH secretagogues developed, with proven efficacy in stimulating GH release in various animal models and human cell-based assays.
Therapeutic Analogs & Context: The knowledge gained from GHRP-2 research directly contributed to the development of later-generation GHSs. Pralmorelin (GHRP-2) has been approved in some countries (e.g., Japan) as a diagnostic agent for GH deficiency.
Research-Driven Insights: Studies using GHRP-2 have been crucial in characterizing the GHSR-1a pathway and understanding the potential benefits and risks (e.g., concomitant cortisol increase) of therapeutic GH stimulation.
Regulatory Status: It is not an FDA-approved drug. Its sale and use are strictly for non-clinical, non-human research purposes. Any human efficacy data is historical and relates to its use as an experimental agent in early-phase research.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.