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Chemicals
Growth Hormone Releasing Factor, GRF (1 – 29), amide, human CAS NO.86168-78-7
Growth Hormone Releasing Factor, GRF (1-29), amide, human (CAS NO. 86168-78-7) is a 29-amino-acid peptide with the molecular formula C₁₄₉H₂₄₆N₄₄O₄₂S and molecular weight 3358.03 g/mol. As a potent stimulator of growth hormone (GH) secretion, it is widely used in endocrinology research, GH deficiency studies, and preclinical development of growth-promoting therapies.
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Growth Hormone Releasing Factor, GRF (1-29), amide, human |
| CAS NO. | 86168-78-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₄₉H₂₄₆N₄₄O₄₂S |
| Molecular Weight | 3358.03 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Human GRF (1-29) amide is a 29-amino-acid peptide and a potent agonist of the growth hormone secretagogue receptor 1a (GHS-R1a; human, EC₅₀: 0.1–1 nM). It stimulates growth hormone (GH) release from the anterior pituitary via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation. C-terminal amidation enhances stability and receptor binding. |
| Storage Conditions | Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GHS-R1a Activation: Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) with high affinity (human, EC₅₀: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.
GH Secretion: Stimulates growth hormone release from the anterior pituitary gland via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation, bypassing hypothalamic somatostatin inhibition.
C-Terminal Amidation: The C-terminal amidation (NH₂) enhances peptide stability in biological fluids and strengthens receptor binding, making it more potent than non-amidated forms.
2.PRODUCT INDICATIONS
Endocrinology Research: Studying GH regulation, puberty, aging-related hormonal changes, and GH deficiency disorders.
Preclinical Drug Development: Screening GHS-R1a agonists/antagonists for treating growth disorders (e.g., dwarfism) or metabolic diseases (e.g., cachexia).
Athletic Performance Studies: Investigating GH’s role in muscle growth, recovery, and exercise physiology (research use only).
3.CLINICAL EFFICACY OF PRODUCT
GH Secretion: In human pituitary cell cultures, GRF (1-29) increased GH release by 5–10x (1 nM concentration) vs. baseline.
Linear Growth: In GH-deficient rodent models, it promoted 30–50% greater body length increase over 8 weeks vs. untreated controls.
Muscle Function: In aged rat models, it improved grip strength by 20–30% and lean muscle mass by 15–25% within 4 weeks.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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