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Chemicals
GRF (1-29) amide (rat) CAS NO.91826-20-9
GRF (1-29) amide (rat) (CAS NO. 91826-20-9) is a 29-amino-acid peptide with the molecular formula C₁₅₅H₂₅₁N₄₉O₄₀S and molecular weight 3473.1 g/mol. As a species-optimized analog of growth hormone-releasing factor for rats, it is a potent agonist of the growth hormone secretagogue receptor 1a (GHS-R1a) and a critical tool for rat-specific endocrinology research, GH regulation studies, and preclinical development of …
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GRF (1-29) amide (rat) |
| CAS NO. | 91826-20-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₅₅H₂₅₁N₄₉O₄₀S |
| Molecular Weight | 3473.1 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Rat-specific GRF (1-29) amide, a 29-amino-acid peptide and potent agonist of the growth hormone secretagogue receptor 1a (GHS-R1a; rat, EC₅₀: 0.1–1 nM). C-terminal amidation enhances stability and receptor binding. Stimulates growth hormone (GH) release from the anterior pituitary via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation. Species-optimized for rat models, critical for comparative endocrinology and translational research. |
| Storage Conditions | Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GHS-R1a Activation: Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in rats with high affinity (EC₅₀: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.
GH Secretion: Stimulates growth hormone (GH) release from the anterior pituitary gland via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation, bypassing hypothalamic somatostatin inhibition.
C-Terminal Amidation: The C-terminal amidation (NH₂) enhances peptide stability in biological fluids and strengthens receptor binding, making it more potent than non-amidated forms.
2.PRODUCT INDICATIONS
Rat Endocrinology Research: Studying GH regulation, puberty, aging-related hormonal changes, and GH deficiency disorders in rat models.
Comparative Studies: Investigating species differences in GRF-GHS-R1a interactions between rats, humans, and other animals.
Preclinical Drug Development: Screening GHS-R1a agonists/antagonists for treating growth disorders (e.g., dwarfism) or metabolic diseases (e.g., cachexia) in rat models.
3.CLINICAL EFFICACY OF PRODUCT
GH Secretion: In rat pituitary cell cultures, GRF (1-29) amide increased GH release by 5–10x (1 nM concentration) vs. baseline.
Linear Growth: In GH-deficient rat models, it promoted 30–50% greater body length increase over 8 weeks vs. untreated controls.
Muscle Function: In aged rat models, it improved grip strength by 20–30% and lean muscle mass by 15–25% within 4 weeks.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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