GLP-2 (rat) CAS NO.195262-56-7

GLP-2 (rat) (CAS 195262-56-7) is the 33-amino acid peptide representing the rat isoform of Glucagon-Like Peptide-2, a key intestinotrophic hormone derived from post-translational processing of proglucagon in intestinal L-cells. This peptide is structurally and functionally related to GLP-1 but exhibits distinct biological activities focused primarily on intestinal growth, repair, and function.

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

Send product inquiry View on supplier website More from this supplier

Source categories

Peptides

About this product

Product information from the supplier.

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GLP-2 (rat)
CAS NO.	95262-56-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C166H256N44O56S
Molecular Weight	3796.22g/mol
Purity (RP-HPLC)	≥95%
Solubility	≥1 mg/mL in water; ≥138.05 mg/mL in DMSO; soluble in aqueous/DMSO mixed system
Endotoxin	≤1.0 EU/mg
Biological Activity	Intestinal epithelium-specific growth factor; stimulates intestinal cell proliferation and inhibits apoptosis
Storage Conditions	Store desiccated at ≤-20°C in dark, dry condition under nitrogen.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Rat GLP-2 exerts its biological effects by binding and activating the specific GLP-2 Receptor (GLP-2R), a G-protein coupled receptor (GPCR) belonging to the glucagon receptor family. The GLP-2R is predominantly expressed on enteroendocrine cells, subepithelial myofibroblasts, and enteric neurons within the gastrointestinal tract, but not on enterocytes themselves. Receptor activation primarily signals through the Gs protein, leading to adenylate cyclase stimulation and increased intracellular cyclic AMP (cAMP).

2.PRODUCT INDICATIONS

Rodent Intestinal Injury & Repair Models: Investigating the therapeutic potential of GLP-2 in experimental models of colitis, intestinal ischemia-reperfusion injury, chemotherapy/radiation-induced mucositis, and small bowel resection (short bowel syndrome).
Gut Mucosal Biology: Studying the mechanisms of crypt cell proliferation, villus growth, and epithelial cell survival in normal and diseased states.
Nutrient Absorption Research: Evaluating the effects of GLP-2 on the expression and function of intestinal nutrient transporters (e.g., for glucose, peptides).
GLP-2 Receptor (GLP-2R) Pharmacology: Using rat-derived cells or tissues to characterize receptor binding, signaling, and the effects of specific agonists/antagonists.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Proof-of-Concept: Extensive research using rat (and human) GLP-2 in animal models demonstrated its potent efficacy in promoting intestinal mucosal growth, reducing injury, and improving function after massive small bowel resection, chemotherapy, or inflammatory damage.
Foundation for Human Therapy: The promising preclinical data with native GLP-2 led to the development of a long-acting, DPP-IV-resistant analog: Teduglutide (Gattex®/Revestive®).
Approved Clinical Drug: Teduglutide is an FDA and EMA-approved drug for the treatment of Short Bowel Syndrome (SBS) in adults and children. It reduces dependence on parenteral nutrition by enhancing intestinal absorption and adaptation, directly translating the biological actions of GLP-2 observed in rat models to human patients.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.