GLP-2 (1-33) (human) CAS NO.223460-79-5

GLP-2 (1-33) (human) (CAS NO. 223460-79-5) is a 33-amino-acid peptide hormone with the molecular formula C₁₆₅H₂₅₄N₄₄O₅₅S and molecular weight 3766.2 g/mol. Derived from the proglucagon gene, it is a key regulator of intestinal growth, mucosal repair, and metabolic homeostasis, making it indispensable for gastroenterology research, regenerative medicine, and therapeutic development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GLP - 2 (1 - 33) (human)
CAS NO.	223460 - 79 - 5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₆₅H₂₅₄N₄₄O₅₅S
Molecular Weight	5040.74g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water or phosphate - buffered
Endotoxin	≤1.0 EU/mg
Biological Activity	GLP - 2 (1 - 33) (human) has significant biological activity. It is known to play a key role in promoting intestinal growth, enhancing intestinal epithelial cell proliferation, and increasing intestinal absorption capacity. In addition, it can modulate the immune response within the gut, protecting the intestinal mucosa from damage and inflammation.
Storage Conditions	To maintain the stability and integrity of GLP - 2 (1 - 33) (human), it should be stored at - 20°C or below in a dry environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GLP-2 Receptor (GLP-2R) Activation: Binds to the GLP-2 receptor (GLP-2R) on intestinal epithelial cells with high affinity (EC₅₀: ~0.1–1 nM), triggering Gαs/cAMP signaling cascades.

Intestinal Mucosal Repair: Stimulates crypt cell proliferation, villus elongation, and tight junction formation, accelerating recovery from mucosal injury (e.g., chemotherapy, radiation, or ischemia).

Anti-Apoptotic Effects: Inhibits intestinal epithelial cell apoptosis via PI3K/Akt pathway activation, preserving barrier function.

Metabolic Regulation: Enhances nutrient absorption (glucose, amino acids) and modulates glucose homeostasis by improving insulin sensitivity in peripheral tissues.

2.PRODUCT INDICATIONS

Gastroenterology Research: Studying intestinal development, mucosal regeneration, and diseases (e.g., short bowel syndrome, inflammatory bowel disease).

Regenerative Medicine: Developing therapies for intestinal injury, surgical resection, or radiation-induced enteritis.

Metabolic Studies: Investigating GLP-2’s role in nutrient absorption, obesity, and type 2 diabetes.

3.CLINICAL EFFICACY OF PRODUCT

Mucosal Repair: In rodent models of chemotherapy-induced enteritis, GLP-2 (1-33) increased villus height by 40–60% and reduced mucosal damage scores by 50% within 7 days.

Nutrient Absorption: In piglets with short bowel syndrome, it enhanced glucose absorption by 30–40% and improved weight gain by 25% over 4 weeks.

Anti-Apoptotic Effects: In human intestinal organoids, it reduced apoptosis by 35–45% under hypoxic conditions (48-hour treatment).

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.