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Chemicals
Calmodulin-Dependent Protein Kinase II (290 – 309) CAS NO.115044-69-4
<p>Calmodulin-Dependent Protein Kinase II (290-309) (CAS 115044-69-4) is a high-purity peptide fragment with the molecular formula C₁₀₃H₁₈₅N₃₁O₂₄S and a molecular weight of 2273.88, engineered for precision research on calcium-calmodulin signaling pathways; this product serves as a critical tool for investigating kinase-mediated cellular processes, including muscle contraction, neurotransmitter release, and gene exp…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Calmodulin-Dependent Protein Kinase II (290-309) |
| CAS NO. | 115044-69-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₀₃H₁₈₅N₃₁O₂₄S |
| Molecular Weight | 2273.88g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water, phosphate-buffered saline (PBS, pH 7.2-7.4), or 0.1% acetic acid. |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Regulates cellular processes such as muscle contraction, neurotransmitter release, gene expression, and cell proliferation via phosphorylation of target proteins. |
| Storage Conditions | Store lyophilized powder at -20°C in a dry, light-protected environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Calcium-Dependent Activation: Binds to calmodulin (CaM) upon intracellular calcium influx, forming a Ca²⁺/CaM-kinase complex that undergoes autophosphorylation and activation.
Substrate Phosphorylation: Phosphorylates serine/threonine residues on target proteins (e.g., synapsin I, myosin light chains, transcription factors), modulating their activity and cellular localization.
Signal Amplification: Acts as a molecular switch to amplify calcium signals, coordinating diverse physiological responses across tissues.
2.PRODUCT INDICATIONS
Neuroscience Research: Studies on synaptic plasticity, neurotransmitter release, and neuronal signaling pathways.
Cardiac Physiology: Investigates calcium handling, contractility, and arrhythmias in cardiomyocytes.
Cell Biology: Elucidates calcium-dependent gene expression, cell proliferation, and apoptosis mechanisms.
Drug Discovery: Screens for kinase inhibitors or activators targeting calcium signaling disorders
3.CLINICAL EFFICACY OF PRODUCT
Preclinical Validation: Demonstrates dose-dependent kinase activity in vitro, with EC₅₀ values validated in CaM-dependent phosphorylation assays using recombinant substrates.
Functional Relevance: Mimics native kinase fragment activity in cellular models, regulating synaptic vesicle trafficking and cardiac myocyte contraction in rodent studies.
Translational Potential: Serves as a benchmark compound for developing therapeutics targeting calcium-calmodulin kinase dysfunction in cardiovascular and neurological diseases.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
