HBV core14, (HBA31)

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

This peptide functions as a defined antigenic target for the adaptive immune system. During a natural HBV infection, antigen-presenting cells process the viral core protein and present fragments like the Core14/HBA31 epitope on Major Histocompatibility Complex (MHC) molecules. When presented by MHC class II, this epitope can activate CD4+ helper T cells, which are crucial for supporting B-cell antibody production and CD8+ T-cell functions.

2.PRODUCT INDICATIONS

• HBV-Specific T-Cell Monitoring: Serving as a stimulus in immune monitoring assays such as Enzyme-Linked Immunospot (ELISPOT) for interferon-gamma (IFN-γ), intracellular cytokine staining (ICS) by flow cytometry, or proliferation assays to quantify and characterize HBV Core14-specific T-cell responses in patient samples (e.g., chronically infected, vaccinated, or resolved individuals).

• Epitope-Specific Antibody Detection: Coating ELISA plates to detect and measure antibodies specifically targeting the Core14 epitope in human serum, aiding in detailed immune profiling.

• Vaccine Immunology: Evaluating the immunogenicity of the Core14 epitope in preclinical studies of therapeutic HBV vaccine candidates, often as part of a peptide cocktail or a DNA vaccine construct, to assess its ability to induce cellular immunity.

• Immune Escape & Viral Mutation Studies: Investigating how mutations within this epitope region affect T-cell or antibody recognition, which is relevant for understanding viral persistence and immune escape in chronic hepatitis B.

• Reagent for Antibody Generation: Conjugating to a carrier protein to generate monoclonal or polyclonal antibodies specific for this region of the HBV core antigen for use in research or diagnostic assays.

3.CLINICAL EFFICACY OF PRODUCT

• Research & Diagnostic Tool Efficacy: Its "efficacy" is its ability to accurately and sensitively detect and quantify HBV-specific T-cell and B-cell responses in research settings, providing valuable immunological data.

• Correlate of Immune Control: In clinical research, strong and multispecific T-cell responses against core epitopes, including those in the Core14 region, are associated with viral clearance in acute infection and with functional cure or immune control in chronic infection. This peptide is used to measure these responses.

• Therapeutic Vaccine Development: The Core14 epitope is a candidate component in investigational therapeutic vaccines for chronic hepatitis B. These vaccines aim to break immune tolerance and restore effective T-cell responses. This peptide is used to design, test, and monitor the immunogenicity of such vaccines in preclinical and clinical trials.

• Clinical Monitoring: Assays using this and similar peptides are used in research to monitor immune reconstitution in patients undergoing antiviral therapy or novel immunotherapies, providing insights into treatment efficacy.




4.DELIVERY & SHIPPING


We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight


We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.