MCH-Gene-Overprinted-Polypeptide-27 (rat)

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

The mechanistic action of rat MCH-Gene-Overprinted-Polypeptide-27 is distinct from that of MCH and is not mediated through the classic MCH Receptor 1 (MCHR1). Its exact cognate receptor(s) remain to be fully elucidated, though research suggests it may act through one or more orphan G-protein coupled receptors (GPCRs). Current evidence indicates it can modulate neuronal activity and signaling pathways, potentially involving Gq/11-mediated calcium mobilization or other second messenger systems. Its biological effects, such as influencing arousal and locomotor activity, appear to be mediated through these independent receptor systems, possibly expressed in overlapping but distinct neural circuits compared to MCH. 

2.PRODUCT INDICATIONS

• Comparative Neuropeptide Research: Investigating the differential expression, processing, and functional roles of the two peptides (MCH and NGE) derived from the same genetic locus in the rat brain.

• In VivoBehavioral Studies: Central administration in rats to study its unique effects on behaviors such as arousal, locomotor activity, anxiety, stress responses, and learning/memory, comparing and contrasting them with MCH effects.

• Receptor Deorphanization & Signaling: Screening for and characterizing putative receptors for this peptide using cell-based assays (e.g., calcium flux, cAMP, β-arrestin recruitment) to identify its specific signaling pathways.

• Gene Expression & Regulation: Studying the transcriptional and translational regulation of the MCH gene locus that leads to the production of this alternative polypeptide.

3.CLINICAL EFFICACY OF PRODUCT

• • Research Tool Efficacy: Its efficacy is defined by its utility in uncovering novel neurobiology. Research has shown it has behavioral effects in rats distinct from MCH, validating it as a functionally independent signaling molecule.

  • Novel Neuropeptide System: Its existence demonstrates the complexity of neuropeptide coding within the genome. Understanding its function may reveal entirely new regulatory systems in the brain with potential relevance to human disorders.

  • Therapeutic Potential: If its receptor is identified and its role in specific behaviors or disease states (e.g., sleep/wake disorders, anxiety, energy balance) is confirmed, it could represent a novel drug target. Drugs modulating this system would be distinct from MCHR1-targeted therapies.

  • Translational Gap: Currently, the human ortholog and its function are less defined. Research in rats is the foundational step to determine if this system is conserved and relevant in humans. There are no current drugs or clinical trials targeting this peptide or its putative receptor.




4.DELIVERY & SHIPPING


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Shipping Methods 
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