Histatin 5 CAS NO.104339-66-4

<p>Histatin 5 is a natural, histidine-rich, cationic antimicrobial peptide consisting of 24 amino acids (DSHAKRHHGYKRKFHEKHHSHRGY). It is one of the major functional peptides derived from the Histatin family, primarily secreted by the parotid and submandibular glands in human saliva. Histatin 5 is renowned for its potent, broad-spectrum antifungal activity, particularly against <em>Candida albicans</em>, and exhibit…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Histatin 5
CAS NO.	104339-66-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C133H195N51O33
Molecular Weight	3036.36g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute PBS (pH 7.0-7.4), 0.1% TFA aqueous solution
Endotoxin	≤1.0 EU/mg
Biological Activity	Endogenous human salivary cationic peptide with broad-spectrum antifungal (anti-Candida albicans) and antibacterial activity
Storage Conditions	Store at -20°C to -80°C in a sealed, dry and light-protected container; avoid repeated freeze-thaw cycles (aliquoting into 0.1-1 mg aliquots recommended).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Histatin 5 exerts its primary antimicrobial effects through a multi-step mechanism culminating in membrane disruption and intracellular targeting. Initially, the cationic peptide binds to negatively charged components on the microbial cell surface (e.g., phospholipids in fungal membranes or lipopolysaccharides in bacteria). This electrostatic interaction is followed by peptide translocation across the membrane without massive pore formation, a process distinct from many pore-forming AMPs. Once inside the fungal cell, Histatin 5 targets mitochondria, where it induces non-lytic efflux of cellular ATP and other small molecules, disrupts mitochondrial membrane potential, and triggers the generation of reactive oxygen species (ROS).

2.PRODUCT INDICATIONS

Antifungal/Antimicrobial Research: Testing in vitrosusceptibility of fungal pathogens (especially Candidaspp.) and bacteria to determine minimum inhibitory concentrations (MICs) and study resistance mechanisms.
Oral Biology & Dental Research: Investigating its role in oral innate immunity, biofilm formation on teeth and mucosal surfaces, and its interaction with other salivary components.
Mechanism of Action Studies: Exploring the detailed steps of fungal cell killing, mitochondrial targeting, and intracellular signaling pathways activated in response to Histatin 5 exposure.
Wound Healing Research: Assessing its potential to promote migration and closure of epithelial cells in models of oral and dermal wound healing.

3.CLINICAL EFFICACY OF PRODUCT

Proven In Vitro& Preclinical Efficacy: It is highly effective at killing Candida albicansand other oral pathogens in laboratory studies.
Clinical Relevance & Therapeutic Potential: Its presence in saliva is considered a key component of oral innate immunity, protecting against opportunistic infections like oral candidiasis
Therapeutic Development Challenges: While highly active, the native peptide is susceptible to proteolytic degradation in physiological environments.
Current Status: No Histatin 5-based drug is currently on the market.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.