Luteinizing Hormone Releasing Hormone LH-RH

<p>Luteinizing Hormone Releasing Hormone (LH-RH), also known as Gonadotropin-Releasing Hormone (GnRH), is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) neurohormone synthesized in the hypothalamus. It is the central regulator of the reproductive axis, governing the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary.</p>

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Luteinizing Hormone Releasing Hormone (LH-RH)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C55H75N17O13
Molecular Weight	1182.4g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute PBS (pH 7.2-7.4), 0.1% TFA aqueous solution .
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous hypothalamic neuropeptide; binds to pituitary gonadotrope LH-RH receptors to stimulate the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
Storage Conditions	Store at -20°C to -80°C in a sealed, dry and light-protected container; avoid repeated freeze-thaw cycles (aliquoting into 0.1-1 mg small volumes recommended).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

LH-RH exerts its effects by binding and activating the specific Gonadotropin-Releasing Hormone Receptor (GnRHR) on the surface of pituitary gonadotrope cells. GnRHR is a G-protein coupled receptor (GPCR) primarily coupled to the Gq/11 protein. Binding triggers phospholipase C (PLC) activation, leading to the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol trisphosphate (IP₃) and diacylglycerol (DAG). IP₃ mobilizes intracellular calcium, while DAG activates protein kinase C (PKC).

2.PRODUCT INDICATIONS

Hypothalamic-Pituitary-Gonadal (HPG) Axis Studies: Investigating the physiological regulation of gonadotropin secretion, pulse generator activity, and feedback mechanisms in vitro(pituitary cell cultures) and in vivo(animal models).
GnRHR Pharmacology: Serving as the native, high-affinity reference agonist in receptor binding assays, signal transduction studies (calcium flux, IP₃ accumulation), and for evaluating competitive antagonists or allosteric modulators.
Diagnostic Medicine (Research Context): Used in the standard GnRH stimulation test to assess pituitary gonadotrope function and reserve in research models, helping diagnose disorders of the HPG axis.
Fertility & Reproductive Research: Studying the hormonal control of ovulation, spermatogenesis, and puberty in animal models.
Drug Discovery: Acting as the benchmark for developing long-acting agonists (used for downregulation) and antagonists of GnRH for therapeutic purposes in cancer and reproductive medicine.

3.CLINICAL EFFICACY OF PRODUCT

Diagnostic Efficacy: In the GnRH stimulation test, a bolus of synthetic LH-RH (e.g., Gonadorelin) is a standard diagnostic tool. The magnitude of the LH/FSH response helps differentiate hypothalamic from pituitary causes of hypogonadism.
Therapeutic Analogs & Paradigm: The understanding of LH-RH physiology led to the development of long-acting GnRH agonists (e.g., Leuprolide, Goserelin) and GnRH antagonists (e.g., Ganirelix, Degarelix).
- Agonists: Initially stimulate, then desensitize the pituitary, leading to medical castration. Used for prostate cancer, breast cancer, endometriosis, uterine fibroids, and central precocious puberty.
- Antagonists: Immediately block the receptor, rapidly suppressing sex hormones. Used in IVF and prostate cancer.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.