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Chemicals
Polistes Mastoparan CAS NO.74129-19-4
<p>Polistes Mastoparan (CAS NO. 74129-19-4) is a synthetic, linear 14-amino acid peptide toxin originally isolated from the venom of <em>Polistes</em>wasps. This amphipathic, α-helix-forming peptide is a high-purity research tool renowned for its potent, direct activation of G-proteins and its ability to permeabilize cell membranes, making it invaluable for studying cell signaling and membrane biology.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Polistes Mastoparan |
| CAS NO. | 74129-19-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C77H127N21O18 |
| Molecular Weight | 1635g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Binds to and inhibits calmodulin (CaM); activates phospholipase A₂; exhibits antimicrobial activity against S. aureus (EC₅₀ = 5 μM) by inducing K⁺ efflux; promotes mast cell degranulation and histamine release. |
| Storage Conditions | Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The peptide exerts its effects through two primary mechanisms. First, it directly binds to and activates pertussis toxin-sensitive heterotrimeric G proteins (Gi/o family), stimulating GTPase activity and downstream signaling without receptor involvement. Second, its cationic and amphipathic structure allows it to insert into phospholipid bilayers, disrupting membrane integrity, forming pores, and facilitating calcium influx and mast cell degranulation.
2.PRODUCT INDICATIONS
This product is indicated for fundamental research in pharmacology, cell biology, and biochemistry. It serves as a critical tool for: investigating non-receptor-mediated G-protein signaling pathways, studying mast cell and basophil activation and histamine release, probing mechanisms of antimicrobial peptides (AMPs), and as a model compound for researching peptide-lipid interactions and membrane poration.
3.CLINICAL EFFICACY OF PRODUCT
Polistes Mastoparan itself is not used as a therapeutic agent. Its efficacy lies in its robust and reliable activity as a research probe. Studies utilizing this peptide have significantly advanced the understanding of G-protein function and membrane disruption, providing foundational knowledge that informs the design of novel drug candidates, including antimicrobial agents and targeted cell-penetrating peptides in preclinical development.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
