Histone H3 (116–136), C116–136

<p>Histone H3 (116–136), C116–136 is a high-purity synthetic peptide corresponding to the C-terminal region (amino acids 116–136) of human histone H3, with a specific modification or labeling at the C-terminus (denoted as C116–136). This peptide represents a critical functional domain involved in nucleosome structure, chromatin dynamics, and epigenetic regulation. The C-terminal modification enables versatile applic…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Histone H3 (116–136), C116–136
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C107H195N39O28S
Molecular Weight	2508.06g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, PBS (pH 7‑8)
Endotoxin	< 1.0 EU/mg
Biological Activity	Histone H3 C-terminal functional fragment (positions 116-136) contains multiple lysine methylations
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Histone H3 (116–136), C116–136 functions as a biologically active fragment of the core histone H3, which is integral to nucleosome assembly and chromatin architecture. The C-terminal tail of histone H3 extends from the nucleosome core and serves as a platform for post-translational modifications (PTMs) such as methylation, acetylation, and phosphorylation. These PTMs constitute the "histone code" that regulates DNA accessibility, transcription factor recruitment, and gene expression. The specific C-terminal modification (C116–136) may facilitate covalent conjugation to solid supports, tags, or probes, enabling the peptide to be used in affinity purification, co-immunoprecipitation, or detection assays. The peptide can also serve as a substrate for histone-modifying enzymes (e.g., methyltransferases, acetyltransferases) in vitro, allowing the study of enzyme kinetics and inhibitor screening.

2.PRODUCT INDICATIONS

Epigenetics Research: Study of histone modifications, chromatin remodeling, and gene regulation mechanisms.

Enzyme Activity Assays: Substrate for histone-modifying enzymes (HATs, HDACs, HMTs, kinases).

Protein Interaction Studies: Investigation of histone-binding proteins, chromatin readers, and transcriptional regulators.

Antibody Production: Immunogen for generating modification-specific or sequence-specific antibodies.

Drug Discovery: Screening for epigenetic drug candidates targeting histone modifications or chromatin regulators.

Conjugation & Labeling Applications: Use in pull-down assays, affinity chromatography, or diagnostic assay development due to C-terminal modifiable group.

3.CLINICAL EFFICACY OF PRODUCT

Functional Versatility: C-terminal modification enables flexible conjugation to tags, beads, or detection molecules.

Research Reproducibility: Consistent performance in enzymatic assays, binding studies, and immunological applications.

Technical Support: Access to application notes and expert consultation for chromatin and epigenetics research.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.