[Ala81] – MBP (74 – 85)

<p>[Ala81]-MBP (74-85) is a synthetic, modified peptide variant derived from the guinea pig myelin basic protein (MBP) sequence. This research-grade antigen features a precise alanine substitution at position 81, designed to study the effects of specific amino acid changes on immunogenicity and encephalitogenicity. It serves as a specialized tool for dissecting the molecular mechanisms of autoimmune demyelination.</…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ala⁸¹]-Myelin Basic Protein (74-85), also known as [Ala81]-MBP (74-85)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C55H94N20O21
Molecular Weight	1371.48g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or neutral buffers
Endotoxin	≤10 EU/mg
Biological Activity	A non-encephalitogenic analog of MBP (74-85), used as a control in studies of experimental autoimmune encephalomyelitis
Storage Conditions	Store at -20°C in a dry, sealed container; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This modified peptide acts as an altered encephalitogenic epitope. The substitution of alanine at a key residue (position 81) within the core MBP (74-85) sequence modulates its interaction with Major Histocompatibility Complex (MHC) class II molecules and T-cell receptors. This change can either attenuate or, in some contexts, alter the characteristics of the induced autoimmune response, making it a valuable probe for studying antigen processing, MHC binding affinity, and the fine specificity of autoreactive T-cell activation in the Experimental Autoimmune Encephalomyelitis (EAE) model.

2.PRODUCT INDICATIONS

This product is indicated for advanced, hypothesis-driven research in neuroimmunology and autoimmune disease. It is specifically used to investigate the impact of defined amino acid substitutions on antigenicity and pathogenicity in EAE models, to study T-cell receptor recognition and epitope specificity, and to support the rational design of altered peptide ligands (APLs) for potential immunomodulatory therapies targeting diseases like multiple sclerosis.

3.CLINICAL EFFICACY OF PRODUCT

[Ala81]-MBP (74-85) is a preclinical research reagent, not a clinical therapeutic. Its efficacy is defined by its utility as a scientific tool. Studies utilizing this and similar modified peptides have been crucial for proving the concept of "altered peptide ligands" and their potential to modulate T-cell responses. This foundational research has informed the development of APL-based therapeutic strategies for autoimmune diseases, some of which have progressed to clinical trials, highlighting the peptide's role in advancing translational immunology.

4.DELIVERY & SHIPPING

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Shipping Methods
Main Method: International Air Freight

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