[Pyr4] – MBP (4 – 14) CAS NO.136132-68-8

<p>[Pyr⁴]-MBP (4-14) (CAS NO. 120881-23-4) is a high-purity synthetic peptide with a molecular formula of C₅₉H₈₇N₂₁O₁₇ and a molecular weight of 1374.48 g/mol. It is a modified analog of the encephalitogenic myelin basic protein (MBP) (4-14) epitope, featuring a pyroglutamic acid substitution at position 4 to enhance stability and biological activity. This lyophilized white to off-white powder exhibits ≥95% purity (…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Pyr⁴]-MBP (4-14)
CAS NO.	136132-68-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C60H100N20O17
Molecular Weight	1391.61g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 1% acetic acid, or DMSO (optimal concentration: 1-10 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	A modified analog of the encephalitogenic MBP (4-14) epitope, which binds to MHC class II molecules (I-Aᵘ) and activates autoreactive T cells. It induces experimental autoimmune encephalomyelitis (EAE) in mice, serving as a key tool for studying multiple sclerosis (MS) pathogenesis.
Storage Conditions	Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Pyr⁴]-MBP (4-14) acts as a high-affinity antigenic peptide that binds to MHC class II molecules (e.g., I-Aᵘ in mice) and activates autoreactive CD4⁺ T cells.

The pyroglutamic acid (Pyr) substitution at position 4 increases peptide stability and MHC binding affinity, leading to more potent and sustained T-cell activation compared to the native MBP (4-14) sequence.

This activation triggers a targeted immune response that mimics the pathological processes of MS, enabling researchers to dissect the molecular basis of autoimmune neuroinflammation and test potential therapies.

2.PRODUCT INDICATIONS

Research Use Only (RUO): For in vitro and in vivo studies of EAE and MS pathogenesis, including MHC-peptide-TCR interactions and T-cell-mediated neuroinflammation.

Ideal for evaluating the efficacy of immunotherapies, such as peptide-based vaccines, monoclonal antibodies, and small-molecule inhibitors, in preclinical models.

Suitable for tolerance-induction experiments and vaccine development aimed at mitigating autoimmune responses in the central nervous system.

3.CLINICAL EFFICACY OF PRODUCT

[Pyr⁴]-MBP (4-14) is a preclinical research tool and has not been evaluated in human clinical trials.

In murine EAE models, it consistently induces a reproducible autoimmune response, serving as a gold-standard positive control for testing novel anti-inflammatory and immunomodulatory agents.

Its well-characterized activity profile supports its use in validating the efficacy of potential MS therapies, including those targeting antigen presentation and T-cell activation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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