Image not available
Chemicals
γ3-MSH CAS NO.72629-64-2
<p>γ3-MSH (Gamma-3-Melanocyte-Stimulating Hormone) is a synthetic neuropeptide corresponding to the C-terminal fragment of the pro-opiomelanocortin (POMC) precursor protein. It is a distinct member of the melanocortin peptide family, recognized for its potent agonistic activity primarily at the melanocortin 3 receptor (MC3R). This high-purity, research-grade peptide is a vital tool for dissecting the complex roles o…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | γ3-MSH |
| CAS NO. | 72629-64-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C126H188N44O37S |
| Molecular Weight | 2943.2g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in deionized water, dilute acetic acid (0.1% v/v) and neutral phosphate buffers (PBS pH 7.0-7.4) |
| Endotoxin | ≤5 EU/mg |
| Biological Activity | Endogenous melanocortin family peptide |
| Storage Conditions | Store at -20°C in a tightly sealed container under desiccation; aliquot into small volumes upon first use to avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
γ3-MSH functions as a selective endogenous agonist for the melanocortin 3 receptor (MC3R), with lower affinity for other melanocortin receptors. Upon binding to MC3R, predominantly expressed in the brain and peripheral tissues, it activates the Gs protein-coupled signaling pathway, leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels. This activation modulates neuronal circuits involved in energy balance, influences aldosterone secretion, and participates in the central control of blood pressure and inflammatory responses.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research in physiology, pharmacology, and endocrinology. Its primary applications include: investigating the specific physiological functions of the MC3 receptor, studying central and peripheral mechanisms of energy homeostasis and feeding behavior, exploring cardiovascular regulation and aldosterone secretion, and serving as a selective reference agonist in receptor binding and functional assays for melanocortin receptor subtype characterization.
3.CLINICAL EFFICACY OF PRODUCT
γ3-MSH is a fundamental research tool, not a direct therapeutic agent. Its efficacy lies in its role as a key pharmacological probe. Studies utilizing γ3-MSH have been instrumental in elucidating the unique, non-redundant roles of MC3R in metabolism (distinct from MC4R) and cardiovascular function. This research provides critical insights that inform the development of novel, receptor-subtype-targeted therapeutics for conditions like obesity, metabolic syndrome, and hypertension.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
More from this supplier
Global Technology Co., Ltd.
