Ac-[Lys0,Nle3]-g2-MSH amide CAS NO.237761-41-0

<p>Ac-[Lys⁰,Nle³]-γ2-MSH amide is a synthetic peptide analog of γ2-melanocyte stimulating hormone (γ2-MSH) featuring specific modifications at the N-terminus (acetylated Lys⁰ addition) and position 3 (Nle substitution) to enhance metabolic stability and receptor selectivity. This research-grade reagent is designed as a selective agonist for melanocortin receptors, with particular affinity for the MC3 receptor subtyp…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Lys0,Nle3]-g2-MSH amide
CAS NO.	237761-41-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C83H116N24O17
Molecular Weight	1722g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, physiological saline, or dilute acetic acid solution. It is recommended to first prepare a high-concentration stock solution (1-5 mg/mL) with a small amount of dilute acetic acid (<0.1% v="">
Endotoxin	< 1.0 EU/mg
Biological Activity	This product is an analogue of γ2-melanocyte-stimulating hormone (γ2-MSH), exhibiting selective agonistic activity against melanocortin receptors (especially MC3R), and participating in the regulation of energy metabolism, appetite, and cardiovascular function. Its bioactivity is typically assessed through in vitro cell cAMP accumulation experiments or physiological indicators such as food intake and blood pressure in animal models. Activity data should be obtained from the specific batch's analysis certificate or verified by the user.
Storage Conditions	Store at -20°C or lower in a dry environment, protected from light. It is stable over the long term. Reconstituted solution: It is recommended to aliquot and store frozen at ≤-20°C, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action involves selective binding to and activation of melanocortin receptor 3 (MC3R), a G-protein coupled receptor predominantly expressed in the hypothalamus and peripheral tissues. Receptor engagement triggers intracellular cAMP accumulation through Gαs protein coupling, leading to downstream signaling cascades that modulate energy expenditure, appetite regulation, and metabolic processes. The N-terminal acetylation and Nle³ substitution enhance peptide stability against enzymatic degradation and improve receptor binding affinity, resulting in prolonged biological activity compared to the native γ2-MSH. This selective MC3R agonism makes it a specific tool for dissecting the physiological roles of this receptor subtype in metabolic homeostasis.

2.PRODUCT INDICATIONS

This γ2-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, energy metabolism, obesity and metabolic syndrome, and cardiovascular regulation. It serves as a selective MC3R agonist in receptor binding assays, functional assays measuring cAMP production, and animal models of metabolic disorders. The product is used to study the role of MC3R in appetite control, energy balance, and glucose homeostasis, as well as in structure-activity relationship studies for developing novel therapeutic compounds targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals, and should be handled by trained research personnel in appropriate laboratory settings.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Ac-[Lys⁰,Nle³]-γ2-MSH amide does not have established clinical efficacy for therapeutic use in human patients. While this peptide analog and related compounds have been studied in preclinical models to understand MC3 receptor physiology and its role in metabolic regulation, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin signaling in energy homeostasis and the identification of potential therapeutic targets for metabolic diseases, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.

4.DELIVERY & SHIPPING

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