[Lys0] – γ – 1 – MSH (41 – 58), amide

The mechanism of action involves binding to melanocortin receptors, primarily MC3R and potentially other receptor subtypes, acting as a ligand that may modulate receptor signaling. The N-terminal lysine addition (Lys⁰) is a structural modification designed to potentially influence receptor interaction, possibly affecting binding affinity, selectivity, or metabolic stability compared to the native γ₁-MSH sequence. Upon receptor engagement, the peptide is expected to trigger intracellular signaling cascades, potentially leading to cAMP accumulation through Gαs protein coupling, similar to other melanocortin peptides, although the specific pharmacological profile and receptor selectivity of this modified analog may differ from the endogenous ligand and require experimental characterization.

This γ₁-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, structure-activity relationships of melanocortin peptides, and the effects of N-terminal modifications on peptide function. It serves as a tool compound in receptor binding assays, functional assays measuring second messenger production, and comparative studies with other melanocortin analogs to understand how specific amino acid modifications influence receptor interaction and biological activity. The product is also used in metabolic regulation research and studies exploring the development of modified peptide therapeutics targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.

As a research reagent, [Lys⁰]-γ₁-MSH (41-58), amide does not have established clinical efficacy for therapeutic use in human patients. This specific peptide analog has not undergone clinical development or received regulatory approval for any medical indication. While γ₁-MSH and related melanocortin peptides have been studied in preclinical models to understand their physiological roles, this particular modified analog remains an investigational research tool used primarily for structure-activity relationship studies and basic research purposes. It has no proven clinical efficacy or safety profile for human use and is intended solely for laboratory research applications.