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Chemicals
Melanocyte Associated Antigen gp 100 (17 – 25)
<p>Melanocyte Associated Antigen gp100 (17-25) is a synthetic peptide epitope corresponding to amino acid residues 17-25 of the human glycoprotein 100 (gp100 or PMEL17). This nonameric peptide is a well-characterized, HLA-A*0201-restricted antigenic determinant and serves as a fundamental research-grade reagent for studying cytotoxic T-lymphocyte (CTL) responses against melanoma and other pigment cell-derived cancer…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Melanocyte Associated Antigen gp100 (17-25) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C38H70N10O11 |
| Molecular Weight | 843.04g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥5 mg/mL), dilute acetic acid, or 5% DMSO in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | HLA-A3-restricted melanoma-associated epitope; induces tumor-specific T-lymphocyte responses; used in cancer immunology research and vaccine development. |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide is processed intracellularly and presented on the surface of antigen-presenting cells (APCs) or melanoma tumor cells in complex with HLA-A*0201 molecules. When recognized by specific CD8+ T-cell receptors (TCRs) on circulating CTLs, it triggers T-cell activation, proliferation, and the release of cytolytic granules (perforin, granzymes). This leads to the targeted lysis and elimination of gp100-expressing tumor cells, constituting a core mechanism of tumor-specific adaptive immunity.
2.PRODUCT INDICATIONS
This product is indicated for in vitro and ex vivo research in tumor immunology and immunotherapy development. Key applications include: monitoring and expanding tumor-infiltrating lymphocytes (TILs) or peripheral blood CTLs specific for melanoma, evaluating the immunogenicity of gp100-targeted cancer vaccines, serving as a critical antigen in MHC multimer staining (e.g., tetramers) for T-cell detection, and conducting T-cell activation and functional assays (ELISpot, intracellular cytokine staining) for both basic research and clinical trial immune monitoring.
3.CLINICAL EFFICACY OF PRODUCT
As a research tool, this peptide itself is not a therapeutic. However, its use has been integral to the clinical development of gp100-targeted immunotherapies. The gp100(17-25) epitope has been a central component in numerous clinical trials involving peptide vaccines and adoptive T-cell transfer for metastatic melanoma.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
