α-Melanocyte Stimulating Hormone (11-13)(MSHa)

<p>α-Melanocyte Stimulating Hormone (11-13), also known as the MSHa tripeptide, is a synthetic fragment comprising the C-terminal amino acids 11-13 (typically Lys-Pro-Val-NH2) of the full α-MSH hormone. This minimal, high-purity peptide is a critical research tool for investigating the specific structural determinants and core pharmacophore responsible for the biological activity of α-MSH at melanocortin receptors.<…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α-Melanocyte Stimulating Hormone (11-13) (MSHa); α-MSH (11-13)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C16H31N5O3
Molecular Weight	341.46g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥100 mg/mL), dilute acetic acid, physiological saline
Endotoxin	< 1.0 EU/mg
Biological Activity	Active fragment of α-MSH; exhibits potent anti-inflammatory, anti-apoptotic and tissue-protective effects; modulates immune responses and oxidative stress
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This ultra-short tripeptide represents the core "message sequence" of α-MSH. While lacking the full potency of the native hormone, it retains the fundamental chemical groups necessary for binding to melanocortin receptors (primarily MC1R). It acts as a partial agonist or weak ligand, allowing researchers to isolate and study the essential receptor interaction motif.

2.PRODUCT INDICATIONS

This product is indicated for fundamental biochemical and pharmacological research. Its primary applications are: defining the minimal active core of α-MSH in structure-activity relationship (SAR) studies, serving as a basic scaffold or reference compound for the design and synthesis of novel melanocortin peptide analogs and mimetics, and as a tool in competitive receptor binding assays to map the critical binding region of the receptor.

3.CLINICAL EFFICACY OF PRODUCT

α-MSH (11-13) is a pure research fragment and not a clinical therapeutic. Its "efficacy" lies in its foundational scientific value. Studies utilizing this minimal sequence have been instrumental in identifying the "active core" of melanocortin peptides, providing the essential blueprint for medicinal chemists. This knowledge has directly enabled the rational design of potent, stable, and selective synthetic analogs (like afamelanotide) that have progressed to clinical use for skin disorders, demonstrating the tripeptide's critical role in translational drug development.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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