Image not available
Chemicals
Atrial Natriuretic Peptide (126-149) (rat) CAS NO.91421-87-3
<p>Atrial Natriuretic Peptide (126-149) (rat) (CAS NO. 91421-87-3) is a synthetic 24-amino acid peptide corresponding to the biologically active C-terminal fragment of rat pro-atrial natriuretic peptide (pro-ANP). This high-purity research reagent represents a key circulating form of ANP and is an essential tool for studying the specific physiological and pharmacological effects of this hormone in rodent models of c…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Peptide (126-149) (rat) |
| CAS NO. | 91421-87-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C104H168N38O33S2 |
| Molecular Weight | 2542.86g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (≥ 10 mg/mL), dilute acids, or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent natriuretic, diuretic, and vasorelaxant activity |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide fragment is a potent endogenous agonist for natriuretic peptide receptors, primarily the guanylyl cyclase-A (GC-A/NPR-A) receptor. Upon binding, it activates the receptor's intrinsic guanylyl cyclase domain, leading to a rapid increase in intracellular cyclic guanosine monophosphate (cGMP) levels.
2.PRODUCT INDICATIONS
This product is indicated for preclinical research in cardiovascular physiology, nephrology, and endocrinology using rat models. Key applications include: investigating the mechanisms of blood pressure regulation and fluid-electrolyte balance, studying the pathophysiology and treatment of hypertension, heart failure, and renal diseases in rodents, serving as a precise reference standard in receptor binding assays and cGMP stimulation studies, and exploring ANP's roles in cardiac hypertrophy and fibrosis.
3.CLINICAL EFFICACY OF PRODUCT
Atrial Natriuretic Peptide (126-149) (rat) is a research tool specific to rodent studies and not a human therapeutic. Its efficacy is defined by its ability to faithfully replicate the biological actions of endogenous ANP in rat models. Research utilizing this specific fragment has been crucial for elucidating the detailed cardiorenal functions of ANP in vivo, providing the foundational data that supports the therapeutic targeting of the natriuretic peptide system. This work directly informs the development of related drugs (e.g., nesiritide, sacubitril/valsartan) and biomarkers (BNP/NT-proBNP) used in human medicine.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
More from this supplier
Global Technology Co., Ltd.
