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Chemicals
[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) CAS NO.142878-79-3
<p>[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS NO. 142878-79-3, Molecular Formula C₁₀₂H₁₆₆N₂₈O₃₀S₃, Molecular Weight 2360.82 g/mol) is a high-purity research-grade peptide (≥98% RP-HPLC) designed for preclinical studies in cardiovascular, renal, and metabolic disease research; as a potent NPR-B agonist, it triggers cGMP-mediated vasorelaxation, natriuresis, and diuresis while inhibiting card…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) |
| CAS NO. | 142878-79-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₀₂H₁₆₆N₂₈O₃₀S₃ |
| Molecular Weight | gg/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Binds to NPR-B with high affinity; exhibits natriuretic, diuretic, vasorelaxant and anti-hypertrophic effects |
| Storage Conditions | -20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acts as a potent agonist of natriuretic peptide receptor B (NPR-B), a guanylate cyclase-coupled receptor expressed in vascular endothelial cells, cardiomyocytes, and renal tubular cells. Upon binding to NPR-B, it stimulates the production of cyclic guanosine monophosphate (cGMP), a second messenger that triggers downstream signaling cascades. This activation leads to vasorelaxation (dilation of blood vessels), natriuresis (sodium excretion), and diuresis (water excretion), while also inhibiting cardiac hypertrophy, fibrosis, and vascular smooth muscle cell proliferation. The Tyr0 modification enhances peptide stability and receptor binding affinity compared to native CNP (32-53), prolonging its biological half-life and therapeutic efficacy.
2.PRODUCT INDICATIONS
Investigation of hypertension, heart failure, and cardiac hypertrophy mechanisms
Study of renal function regulation, sodium/water homeostasis, and chronic kidney disease (CKD)
Evaluation of vascular remodeling, atherosclerosis, and endothelial dysfunction
Development of novel therapeutics for diabetic nephropathy and metabolic syndrome
Basic research on natriuretic peptide signaling pathways and NPR-B ligand-receptor interactions
3.CLINICAL EFFICACY OF PRODUCT
Investigation of hypertension, heart failure, and cardiac hypertrophy mechanisms
Study of renal function regulation, sodium/water homeostasis, and chronic kidney disease (CKD)
Evaluation of vascular remodeling, atherosclerosis, and endothelial dysfunction
Development of novel therapeutics for diabetic nephropathy and metabolic syndrome
Basic research on natriuretic peptide signaling pathways and NPR-B ligand-receptor interactions
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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