Image not available
Chemicals
Atrial Natriuretic Factor (4-28) (human) CAS NO.95896-08-5
<p>Atrial Natriuretic Factor (4-28) (human) (CAS NO. 95896-08-5) is a synthetic peptide fragment corresponding to amino acid residues 4-28 of the human atrial natriuretic peptide (ANP/ANF). This high-purity, 25-amino acid sequence represents a truncated yet biologically active form of the hormone and serves as a crucial research tool for studying the structure-activity relationships and specific cardiovascular effec…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
Source categories
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Factor (4-28) (human) |
| CAS NO. | 95896-08-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C112H175N39O35S3 |
| Molecular Weight | 2724.06g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid; sparingly soluble in methanol |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent agonist for natriuretic peptide receptor-A (NPR-A); EC₅₀ ≈ 0.3–1.2 nM in cGMP accumulation assays. |
| Storage Conditions | Store at ≤ -20°C in a dry, dark environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide fragment retains the core structural ring formed by a disulfide bond, which is essential for receptor binding and biological activity. It functions as an agonist for the natriuretic peptide receptor A (NPR-A/GC-A).
2.PRODUCT INDICATIONS
This product is indicated for in vitro and in vivo research in cardiovascular physiology, nephrology, and endocrinology. Primary applications include: studying the minimal active structure of ANP, investigating receptor binding affinity and selectivity, serving as a reference standard in cGMP stimulation and receptor binding assays, and exploring the cardiovascular and renal effects of ANP fragments in preclinical models of hypertension, heart failure, and fluid-electrolyte balance.
3.CLINICAL EFFICACY OF PRODUCT
Atrial Natriuretic Factor (4-28) (human) is a research-grade peptide and not an approved therapeutic. Its "efficacy" lies in its significant scientific value for understanding the ANP system. Research utilizing this and similar fragments has been pivotal in identifying the core receptor-binding domain of ANP, which directly informed the development of clinically relevant analogs and drugs targeting the natriuretic peptide pathway .
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
More from this supplier
Global Technology Co., Ltd.
