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Chemicals
Biotin-Atrial Natriuretic Peptide (1-28), human, porcine
<p>Biotin-Atrial Natriuretic Peptide (1-28), human, porcine is a synthetic, biotin-conjugated analog of the full-length, bioactive 28-amino acid atrial natriuretic peptide (ANP). This high-purity, dual-functional reagent preserves the native biological activity of ANP while incorporating a biotin tag, enabling its specific capture, detection, and immobilization in streptavidin-based assay systems for advanced cardio…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Atrial Natriuretic Peptide (1-28), human, porcine |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C137H217N47O41S4 |
| Molecular Weight | 308.8/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid |
| Endotoxin | ≤1.0 /mg |
| Biological Activity | Potent agonist for natriuretic peptide receptor-A (NPR-A); EC₅₀ ≈ 0.2–1.0 nM in cGMP accumulation assays. |
| Storage Conditions | Store at ≤ -20°C in a dry, dark environment. After reconstitution, store at 4°C for up to 1 week or ≤ -20°C for long-term storage. Avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This conjugate functions as a full agonist for the natriuretic peptide receptor A (NPR-A/GC-A). The biotin moiety, attached via a linker, does not interfere with the peptide's core structure necessary for receptor binding. Upon binding to NPR-A, it activates the receptor's intrinsic guanylyl cyclase activity, leading to increased intracellular cyclic guanosine monophosphate (cGMP) production.
2.PRODUCT INDICATIONS
This product is indicated for sophisticated research applications in molecular pharmacology and assay development. Key uses include: immobilization for surface plasmon resonance (SPR) or biolayer interferometry (BLI) to study ANP-NPR-A binding kinetics, pull-down assays to isolate and identify receptor complexes or interacting proteins, development of sensitive ELISA or other immunoassays for ANP detection, and as a probe for receptor localization studies using streptavidin-based detection methods.
3.CLINICAL EFFICACY OF PRODUCT
Biotin-ANP (1-28) is a research tool, not a therapeutic. Its efficacy is defined by its critical role in enabling high-precision analytical techniques. By facilitating detailed biophysical and biochemical studies of the ANP-NPR-A interaction, this reagent contributes to the fundamental understanding of natriuretic peptide signaling.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
