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Chemicals
Atrial Natriuretic Peptide (4-24), frog CAS NO.118691-44-4
<p>Atrial Natriuretic Peptide (4-24), frog (CAS NO. 118691-44-4) is a high‑purity synthetic peptide corresponding to a bioactive segment of frog atrial natriuretic peptide.This peptide is widely used in cardiovascular, renal, and endocrine research to study blood pressure regulation and fluid‑electrolyte balance.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Atrial Natriuretic Peptide (4‑24), frog |
| CAS NO. | 118691-44-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C93H152N34O27S3 |
| Amino Acid Sequence | Ser‑Leu‑Arg‑Arg‑Ser‑Ser‑Cys‑Phe‑Gly‑Gly‑Arg‑Ile‑Asp‑Arg‑Ile‑Gly‑Ala‑Gln‑Ser‑Gly‑Leu‑Gly‑Cys‑Asn‑Ser‑Phe‑Arg‑Tyr (frog ANP 4‑24; disulfide bond between Cys⁷ and Cys²³) |
| Molecular Weight | 2273.64g/mol |
| Purity (RP-HPLC) | ≥95.0% (can be customized to ≥98.0%) |
| Solubility | Soluble in water, 0.1 M acetic acid, or phosphate‑buffered saline (PBS) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Natriuretic peptide hormone; binds to natriuretic peptide receptors (NPR‑A/NPR‑B), stimulates cGMP production, and promotes diuresis, natriuresis, and vasodilation in cardiovascular and renal physiology research. |
| Storage Conditions | Store at –20 °C, protected from light and moisture. For long‑term storage, recommend –80 °C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
Atrial Natriuretic Peptide (4-24), frog binds to natriuretic peptide receptors (NPR‑A and NPR‑B), activating intracellular cyclic guanosine monophosphate (cGMP) signaling. This leads to vasodilation, increased renal sodium excretion (natriuresis), and enhanced diuresis, collectively contributing to the reduction of blood pressure and regulation of fluid volume.
2.PRODUCT INDICATIONS
This peptide is employed in preclinical research focused on hypertension, heart failure, renal physiology, and fluid‑balance disorders. It is also used in receptor‑binding assays, signal‑transduction studies, and the evaluation of novel therapeutic agents targeting the natriuretic peptide system.
3.CLINICAL EFFICACY OF PRODUCT
While not intended for direct clinical use, Atrial Natriuretic Peptide (4-24), frog has demonstrated significant efficacy in animal models, effectively lowering blood pressure and modulating fluid homeostasis. These preclinical findings support its utility as a research tool for investigating cardiovascular and renal pathologies and for guiding the development of potential therapeutics.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
