[Tyr0]-Prepro-Atrial Natriuretic Factor (104-123) (human) CAS NO.309245-24-7

<p>[Tyr0]-Prepro-Atrial Natriuretic Factor (104-123) (human) | CAS 309245-24-7 – High-purity (≥98% RP-HPLC) research-grade prohormone fragment with molecular formula C₁₀₃H₁₈₀N₃₂O₃₀ and molecular weight 2346.8 g/mol. Ideal for studying ANF precursor processing, corin/furin enzyme activity, and cardiovascular biomarker development. Features low endotoxin (<0.1 EU/μg) and enhanced stability via Tyr0 modification. Custo…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr0]-Prepro-Atrial Natriuretic Factor (104-123) (human)
CAS NO.	309245-24-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₀₃H₁₈₀N₃₂O₃₀
Molecular Weight	2346.8g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Precursor fragment of atrial natriuretic factor (ANF); acts as a prohormone intermediate, supports research on ANF processing pathways; may exhibit weak NPR-A agonist activity (context-dependent)
Storage Conditions	-20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Tyr0]-Prepro-Atrial Natriuretic Factor (104-123) (human) is a Tyr0-modified prohormone fragment derived from the prepro-atrial natriuretic factor (prepro-ANF) precursor, serving as a key intermediate in the biosynthetic pathway of mature atrial natriuretic factor (ANF). It acts as a substrate for proteolytic processing enzymes (e.g., corin, furin) that cleave the precursor to generate biologically active ANF peptides. While it exhibits weak direct agonist activity for natriuretic peptide receptor A (NPR-A) compared to mature ANF, its primary biological role is to support the study of ANF maturation, processing, and secretion. The Tyr0 modification enhances peptide stability and solubility, facilitating in vitro and in vivo research on the regulation of natriuretic peptide biosynthesis and signaling cascades linked to cardiovascular and renal homeostasis.

2.PRODUCT INDICATIONS

Investigation of ANF precursor processing, maturation, and secretion mechanisms in atrial cardiomyocytes

Study of regulatory pathways of natriuretic peptide biosynthesis and their role in hypertension and heart failure

Evaluation of proteolytic enzyme activity (corin/furin) and its impact on ANF bioavailability

Development of therapeutic strategies targeting ANF precursor processing for cardiovascular disease

3.CLINICAL EFFICACY OF PRODUCT

In atrial myocyte cultures, it serves as a reliable substrate to measure corin/furin activity, enabling screening of compounds that modulate ANF processing.

In hypertensive rodent models, it aids in elucidating the link between impaired ANF precursor cleavage and elevated blood pressure, supporting the development of pro-protein convertase modulators.

In heart failure models, it helps characterize dysregulated ANF biosynthesis, providing insights into the pathophysiology of cardiac remodeling and natriuretic peptide deficiency.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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