Neurokinin A (4-10) CAS NO.97559-35-8

<p>Neurokinin A (4-10) | CAS 97559-35-8 is a high-purity (≥98% RP-HPLC) research-grade peptide with molecular formula C₃₄H₅₄N₈O₁₀S and molecular weight 766.92 g/mol. As a selective NK2R agonist, it is ideal for studying smooth muscle contraction, pain signaling, and neuro-inflammatory responses, featuring low endotoxin (<0.1 EU/μg) and reliable biological activity. We provide customizable bulk orders (10 mg–100 g) a…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurokinin A (4-10)
CAS NO.	97559-35-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₃₄H₅₄N₈O₁₀S
Molecular Weight	766.92g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective agonist of neurokinin 2 receptor (NK2R); induces smooth muscle contraction, stimulates neuropeptide release, and modulates pain signaling pathways
Storage Conditions	-20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neurokinin A (4-10) is a biologically active fragment of the endogenous neuropeptide Neurokinin A, functioning as a highly selective agonist of the neurokinin 2 receptor (NK2R), a G-protein coupled receptor (GPCR) widely expressed in smooth muscle tissues, central nervous system (CNS), and immune cells. Upon binding to NK2R, it activates intracellular signaling pathways via Gq/11 proteins, triggering the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol trisphosphate (IP3) and diacylglycerol (DAG). This cascade leads to increased intracellular calcium levels, which induces smooth muscle contraction (especially in the gastrointestinal, respiratory, and urogenital tracts). Additionally, it modulates pain signaling pathways in the CNS by interacting with sensory neurons, stimulates the release of other neuropeptides, and regulates immune cell activation, contributing to neuro-inflammatory responses.

2.PRODUCT INDICATIONS

Investigating the role of NK2R signaling in smooth muscle contraction and motility

Studying pain transmission, neuro-inflammatory responses, and neuropeptide network regulation in the CNS

Evaluating NK2R antagonist/agonist drug candidates for treating respiratory diseases (e.g., asthma, chronic obstructive pulmonary disease) and gastrointestinal disorders (e.g., irritable bowel syndrome)

Developing in vitro assays for NK2R ligand screening and receptor-ligand interaction studies

3.CLINICAL EFFICACY OF PRODUCT

In isolated smooth muscle preparations (e.g., guinea pig ileum, human bronchial tissue), it reliably induces concentration-dependent contraction, serving as a gold standard for evaluating NK2R antagonist potency

In murine models of asthma, it exacerbates airway hyperresponsiveness and inflammation, mimicking pathological conditions to test anti-asthmatic drug efficacy

In pain models, it enhances nociceptive signaling, enabling the screening of analgesic compounds targeting the neurokinin system

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.