[Tyr0] – Neurokinin B

<div class="ybc-p">[Tyr⁰]-Neurokinin B is a synthetic, N-terminally tyrosine-modified analog of the endogenous tachykinin peptide Neurokinin B, designed primarily for radiolabeling and receptor binding studies. This research-grade peptide retains the full biological sequence of Neurokinin B with an additional tyrosine residue at position 0, providing a convenient site for radioiodination while maintaining high affin…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr0] - Neurokinin B
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C64H88N14O16S2
Molecular Weight	1373.63 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). It is recommended to first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with the desired assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	[Tyr⁰]-Neurokinin B is a modified tachykinin peptide that acts as a high‑affinity agonist at neurokinin‑3 receptors (NK₃R). It elicits characteristic tachykinin responses such as smooth‑muscle contraction, vasodilation, and neuronal excitation. The added tyrosine residue may facilitate iodination for tracer preparation in receptor‑binding studies. Activity should be validated in NK₃R‑expressing cell‑based assays (e.g., calcium flux or IP₃ accumulation).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a potent agonist at neurokinin-3 receptors (NK₃R), binding to the extracellular domain of these G protein-coupled receptors with high affinity. This interaction activates phospholipase C via Gq/11 coupling, leading to increased intracellular inositol trisphosphate (IP₃) and diacylglycerol (DAG) production. The resulting calcium mobilization from intracellular stores triggers smooth muscle contraction, neuronal excitation, and vasodilation in target tissues. The [Tyr⁰] modification does not alter this canonical signaling pathway but provides a phenolic hydroxyl group for efficient iodination, enabling the generation of radioligands that retain full receptor activation capacity.

2.PRODUCT INDICATIONS

This modified Neurokinin B analog is indicated exclusively for research use in preclinical studies of tachykinin receptor biology and neuroendocrine signaling. It is employed as a precursor for radioiodination to produce [¹²⁵I]-Tyr⁰-NKB tracers for receptor binding assays, autoradiography, and saturation/competition studies in brain, pituitary, and peripheral tissues. The unlabeled peptide serves as a cold competitor in displacement experiments and can be used in functional assays to assess calcium flux, IP₃ accumulation, and smooth muscle contraction in NK₃R-expressing cell lines and tissue preparations. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent and radioligand precursor, [Tyr⁰]-Neurokinin B has no established clinical efficacy for therapeutic use in human patients. The product has not undergone clinical development, regulatory approval, or safety evaluation for any medical indication. While it contributes to the understanding of NK₃R signaling in conditions such as polycystic ovary syndrome, hot flashes, and cardiovascular regulation, it remains an investigational tool for basic and translational research. Its utility is confined to laboratory applications, with no proven clinical benefits or safety profile in humans.

4.DELIVERY & SHIPPING

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