Biotin – Neurokinin A

<p>Biotin-Neurokinin A (Biotin-NKA) is a high-purity (≥98% RP-HPLC) biotinylated peptide with molecular formula C₆₀H₉₄N₁₆O₁₆S₂ and molecular weight 1359.64 g/mol. As a selective NK2R agonist retaining native NKA biological activity, it enables streptavidin-mediated tracing, purification, and receptor binding studies, ideal for neuroscience, pharmacology, and diagnostic R&D. Featuring low endotoxin (<0.1 EU/μg) and c…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin - Neurokinin A
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₀H₉₄N₁₆O₁₆S₂
Molecular Weight	gg/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in distilled water, PBS buffer (pH 7.2-7.4); slightly soluble in ethanol; add small amount of dilute acetic acid or DMF to improve solubility if needed
Endotoxin	< 1.0 EU/mg
Biological Activity	Retains Neurokinin A activity; selective agonist of neurokinin 2 receptor (NK2R); mediates smooth muscle contraction, inflammation response, and pain signaling; biotin moiety enables specific binding with streptavidin for tracing, detection and purification
Storage Conditions	-20℃ (short-term, 1-2 years) or -80℃ (long-term, 3-5 years) in dry, dark environment
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Biotin-Neurokinin A is a biotinylated derivative of endogenous Neurokinin A (NKA), a member of the tachykinin neuropeptide family, that retains full biological activity of native NKA while enabling streptavidin-mediated tracing and detection. It acts as a selective agonist of the neurokinin 2 receptor (NK2R), a G-protein coupled receptor (GPCR) widely distributed in smooth muscle tissues, central nervous system (CNS), and immune cells. Upon binding to NK2R, it activates Gq/11-dependent intracellular signaling pathways, triggering phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis to generate inositol trisphosphate (IP3) and diacylglycerol (DAG). This cascade elevates intracellular calcium levels, inducing smooth muscle contraction, modulating pain signaling, and promoting inflammatory responses. The covalently linked biotin moiety (at the N-terminus) specifically binds to streptavidin/avidin with high affinity, facilitating peptide purification, receptor localization, and ligand-receptor interaction analysis without compromising NK2R binding capacity.

2.PRODUCT INDICATIONS

Localization and visualization of neurokinin 2 receptor (NK2R) expression in tissues and cells via streptavidin-conjugated detection systems (e.g., fluorescence, chemiluminescence)

Purification of NK2R and associated signaling complexes using biotin-streptavidin affinity chromatography

Screening and validation of NK2R agonists/antagonists in in vitro assays (e.g., competitive binding assays, calcium mobilization assays)

Study of NKA-NK2R signaling pathways in smooth muscle contraction, pain transmission, and neuro-inflammatory responses

3.CLINICAL EFFICACY OF PRODUCT

In receptor binding assays, it serves as a reliable positive control and tracer to quantify NK2R expression in human tissue samples, aiding in the diagnosis of NK2R-related disorders

In murine models of asthma and irritable bowel syndrome (IBS), it mimics endogenous NKA activity to induce pathological responses, enabling the evaluation of NK2R-targeted drug efficacy

It facilitates the characterization of NK2R signaling dynamics in pain models, supporting the development of analgesic compounds targeting the tachykinin system

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.