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Chemicals
Biotin-Neurokinin B CAS NO.1926163-17-8
<p>Biotin-Neurokinin B (CAS 1926163-17-8) is a high-purity (≥98% RP-HPLC) biotinylated peptide with molecular formula C₆₇H₈₇N₁₅O₁₄ and molecular weight 1326.53 g/mol. As a selective NK3R agonist retaining native NKB activity, it enables streptavidin-mediated tracing, purification, and receptor binding studies, ideal for HPG axis research, neuroscience, oncology, and diagnostic R&D. Featuring low endotoxin (<0.1 EU/μ…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Neurokinin B |
| CAS NO. | 1926163-17-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₀H₉₄N₁₆O₁₆S₂ |
| Molecular Weight | 1359.64g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in distilled water, PBS buffer (pH 7.2-7.4); slightly soluble in ethanol; add small amount of dilute acetic acid or DMF to improve solubility if needed |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Retains Neurokinin A activity; selective agonist of neurokinin 2 receptor (NK2R); mediates smooth muscle contraction, inflammation response, and pain signaling; biotin moiety enables specific binding with streptavidin for tracing, detection and purification |
| Storage Conditions | -20℃ (short-term, 1-2 years) or -80℃ (long-term, 3-5 years) in dry, dark environment |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Biotin-Neurokinin B is a biotinylated derivative of endogenous Neurokinin B (NKB), a key member of the tachykinin peptide family, that retains the full biological activity of native NKB while enabling streptavidin/avidin-based applications. It acts as a highly selective agonist of the neurokinin 3 receptor (NK3R), a G-protein coupled receptor (GPCR) predominantly expressed in the central nervous system (CNS), hypothalamus, and certain tumor cells. Upon binding to NK3R, it activates Gq/11-dependent intracellular signaling pathways, triggering the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol trisphosphate (IP3) and diacylglycerol (DAG), which in turn elevates intracellular calcium levels. This signaling cascade regulates the hypothalamic-pituitary-gonadal (HPG) axis, mediates neuronal transmission, and modulates tumor cell proliferation. The N-terminally conjugated biotin moiety binds specifically to streptavidin/avidin with high affinity, facilitating NK3R localization, ligand-receptor interaction analysis, and receptor purification without compromising NKB’s biological activity or NK3R binding specificity.
2.PRODUCT INDICATIONS
Localization and visualization of neurokinin 3 receptor (NK3R) expression in tissues and cells using streptavidin-conjugated detection systems (e.g., fluorescence, chemiluminescence, and immunohistochemistry)
Purification of NK3R and associated signaling complexes via biotin-streptavidin affinity chromatography for protein structure and function studies
Screening and validation of NK3R agonists/antagonists in in vitro assays (e.g., competitive binding assays, calcium mobilization assays, and cell proliferation assays)
3.CLINICAL EFFICACY OF PRODUCT
In receptor binding assays, it serves as a reliable positive control and tracer to quantify NK3R expression in human tissue samples, aiding in the diagnosis and prognosis of NK3R-related disorders
In murine models of reproductive disorders and neurological diseases, it mimics endogenous NKB activity to induce pathological signaling, enabling the evaluation of NK3R-targeted drug efficacy
In oncology research, it facilitates the characterization of NK3R-mediated tumor cell proliferation, supporting the development of anti-tumor therapies targeting the NKB-NK3R pathway
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
