Neuromedin (U25), porcine CAS NO.98395-76-7

<p>Neuromedin U25, porcine (CAS NO. 98395-76-7) is a synthetic, 25-amino acid peptide representing the porcine isoform of Neuromedin U (NMU). This research-grade neuropeptide is a potent endogenous ligand for the Neuromedin U receptors (NMUR1 and NMUR2). It is a key tool for studying the diverse physiological roles of the NMU system, including energy homeostasis, stress response, gastrointestinal motility, and cardi…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin U25 (porcine)
CAS NO.	98395-76-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C144H217N43O37
Molecular Weight	3142.6/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & dimethyl sulfoxide
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist for neuromedin U receptor 1 (NMU1) and neuromedin U receptor 2.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its effects by binding to and activating two G protein-coupled receptors, NMUR1 (peripheral) and NMUR2 (central). Receptor activation primarily stimulates Gq protein signaling, leading to phospholipase C (PLC) activation, inositol trisphosphate (IP3) production, and a rise in intracellular calcium. This signaling cascade mediates its biological effects, which include smooth muscle contraction in the gut and uterus, modulation of appetite and energy expenditure in the hypothalamus, and influence on local blood flow and inflammation.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in physiology, pharmacology, and endocrinology. Key applications include: studying the role of NMU in regulating food intake, body weight, and energy balance; investigating its effects on gastrointestinal smooth muscle contraction and motility; exploring its functions in cardiovascular tone, stress response, and immune modulation; and serving as a reference agonist for receptor binding and functional assays targeting NMUR1 and NMUR2.

3.CLINICAL EFFICACY OF PRODUCT

Neuromedin U25, porcine is a research tool and not a human therapeutic. Its efficacy is defined by its critical role in elucidating the fundamental biology of the NMU system. Research using this peptide has been instrumental in identifying NMU as a significant regulator of energy homeostasis and gastrointestinal function.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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