Neuromedin (U25), human CAS NO.312306-89-1

<p>Neuromedin U-25, human is the full-length 25-amino acid endogenous neuropeptide that serves as the native ligand for neuromedin U receptors (NMUR1 and NMUR2). This research-grade peptide is synthesized to high purity (≥95% HPLC) with low endotoxin levels and supplied as a lyophilized powder. It is specifically designed for studies of human NMU biology, providing species-relevant data for investigating energy home…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin (U25), human
CAS NO.	312306-89-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C141H203N41O38
Molecular Weight	3080.44g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Human Neuromedin U-25 is an endogenous neuropeptide that acts as a potent agonist at the neuromedin U receptors (NMUR1 and NMUR2). It regulates diverse physiological functions including energy homeostasis, appetite suppression, smooth muscle contraction, stress response, and circadian rhythms. Activity can be confirmed in NMUR-expressing cell-based assays (e.g., calcium flux or cAMP inhibition).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by binding with high affinity to G protein-coupled receptors NMUR1 and NMUR2, primarily coupling to Gq/11 proteins. Activation stimulates phospholipase C, leading to inositol trisphosphate (IP3) production, intracellular calcium mobilization, and inhibition of cAMP accumulation. This signaling cascade modulates diverse physiological processes including smooth muscle contraction, appetite suppression, energy expenditure, and neuroendocrine responses. The human-specific sequence ensures accurate representation of native NMU signaling in human-derived cell systems and translational research models.

2.PRODUCT INDICATIONS

Neuromedin U-25, human is indicated exclusively for research applications in studies of human neuropeptide signaling and physiology. It is employed to investigate NMU's roles in human energy metabolism, appetite control, gastrointestinal motility, stress responses, and potential involvement in metabolic disorders. The product serves as a reference agonist for validating human NMUR1/NMUR2 expression, screening receptor modulators, and characterizing NMU signaling pathways in human cell lines and translational models. It is not intended for diagnostic, therapeutic, or clinical use in humans.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuromedin U-25, human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of human NMU biology and identifies potential therapeutic targets for obesity, metabolic syndrome, and gastrointestinal disorders, its utility remains confined to laboratory research. Any clinical translation would require development of optimized therapeutics with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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