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Chemicals
Neuromedin (B-30)
<p>Neuromedin B-30 is a synthetic peptide representing the C-terminal 30-amino acid fragment of the larger prepro-neuromedin B precursor protein. This research-grade peptide is the processed, biologically active form of the mammalian bombesin-related peptide, neuromedin B (NMB). As a high-affinity ligand for the neuromedin B receptor (NMBR, BB1), it is a critical tool for studying the physiological and pathological …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuromedin B-30 |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C157H243N51O38S |
| Molecular Weight | 3485.07/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid and DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent and selective agonist for bombesin receptor subtype-3 (BRS-3) and neuromedin B (NMB) receptors |
| Storage Conditions | Store at ≤ -20°C in a dry, dark, sealed container. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Neuromedin B-30 exerts its effects by selectively binding to and activating the G protein-coupled neuromedin B receptor (NMBR or BB1). This binding triggers the receptor to primarily couple with the Gq protein, leading to the activation of phospholipase C (PLC). PLC activation results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
2.PRODUCT INDICATIONS
This product is indicated for advanced research in neuroendocrinology, oncology, and smooth muscle physiology. Key applications include: studying the specific roles of NMBR signaling in central and peripheral tissues, investigating its effects on smooth muscle contraction in the gastrointestinal and reproductive tracts, exploring its mitogenic and proliferative actions in cancer models (e.g., lung, prostate, breast), and serving as a selective reference agonist in receptor binding and functional assays to distinguish NMBR activity from other bombesin receptor subtypes
3.CLINICAL EFFICACY OF PRODUCT
Neuromedin B-30 is a preclinical research compound, not a direct therapeutic. Its "efficacy" lies in its role as a highly selective pharmacological tool. Research utilizing this peptide has been pivotal in defining the distinct functions of the NMBR pathway, separate from the gastrin-releasing peptide receptor (GRPR). This work has validated NMBR as a potential diagnostic and therapeutic target, particularly in oncology.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
