Biotin-Neuromedin B

<p>Biotin-Neuromedin B is a biotinylated analog of the endogenous neuromedin B peptide, designed for sensitive detection and isolation of neuromedin B receptor (NMBR/BB1) complexes. The peptide retains high affinity for NMBR while incorporating a biotin tag via a flexible linker, enabling robust interaction with streptavidin-based detection systems. Supplied as a lyophilized powder with ≥95% HPLC purity and low endo…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Neuromedin B
CAS NO.
Appearance	White to off-white lyophilized powder
Molecular Formula	C62H87N17O14S2
Molecular Weight	1358.62g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	Biotin-Neuromedin B is a conjugated analog of the endogenous bombesin-related peptide. It retains high affinity for the neuromedin B receptor (NMBR, BB1), allowing its use as a probe in receptor binding studies, pull-down assays, and immunohistochemistry when paired with streptavidin detection systems. Activity should be validated in relevant NMBR binding or functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a high-affinity agonist for the neuromedin B receptor (NMBR), a G protein-coupled receptor that primarily couples to Gq/11 proteins. Binding to NMBR activates phospholipase C, leading to inositol trisphosphate (IP3) production, intracellular calcium mobilization, and downstream signaling events involved in smooth muscle contraction, cell proliferation, and neuroendocrine regulation. The biotin moiety does not interfere with receptor engagement but provides a handle for streptavidin-mediated detection and capture, facilitating visualization and isolation of receptor-ligand complexes.

2.PRODUCT INDICATIONS

Biotin-Neuromedin B is indicated exclusively for research applications in studies of bombesin receptor biology and signaling. It is employed for NMBR binding assays, receptor autoradiography, pull-down and affinity purification of receptor complexes, immunohistochemistry, flow cytometry, and cellular imaging in both fixed and live-cell systems. The product serves as a critical tool for mapping NMBR expression, validating receptor antibodies, and screening modulators of bombesin receptor signaling pathways. It is not intended for diagnostic, therapeutic, or clinical use in humans.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Biotin-Neuromedin B has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NMBR biology and potential therapeutic targets in cancer, gastrointestinal disorders, and metabolic diseases, its utility remains confined to laboratory research. Any translation to clinical applications would require development of unmodified therapeutic analogs with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.