Neuromedin S (rat) CAS NO.843782-19-4

<p>Neuromedin S (rat) (CAS 843782-19-4) is a high-purity (up to ≥98% RP-HPLC) endogenous peptide with molecular formula C₁₉₃H₃₀₇N₅₇O₄₉S and molecular weight 4242.02 g/mol (free base). As a potent NMU1/NMU2 receptor agonist (EC₅₀=65 pM/91 pM), it regulates circadian rhythm, food intake, and calcium signaling, ideal for neuroscience, chronobiology, and metabolic research. Featuring customizable salt forms, bulk order …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin S (rat)
CAS NO.	843782-19-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₉₃H₃₀₇N₅₇O₄₉S
Molecular Weight	4242.02g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in sterile water
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent endogenous agonist of neuromedin U (NMU) receptors (NMU1 and NMU2), EC₅₀=65 pM (NMU1) and 91 pM (NMU2); regulates circadian rhythm phase shifts, suppresses food/water intake, increases plasma vasopressin levels, and modulates intracellular calcium concentrations
Storage Conditions	-20℃ for short-term storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuromedin S (rat) is a 36-amino acid, C-terminally amidated endogenous peptide that acts as a potent agonist of neuromedin U (NMU) receptors, including both NMU1 and NMU2 subtypes, with exceptional binding affinity (EC₅₀=65 pM for NMU1 and 91 pM for NMU2). As a key regulator in multiple physiological pathways, it exerts its biological effects by activating G-protein coupled receptor (GPCR)-mediated intracellular signaling cascades upon binding to NMU receptors.

2.PRODUCT INDICATIONS

Investigation of NMU1/NMU2 receptor signaling pathways and their roles in circadian rhythm regulation, energy homeostasis, and stress responses

Screening and validation of NMU receptor agonists/antagonists via in vitro assays (receptor binding, calcium mobilization, and functional activity assays)

Study of species-specific peptide-receptor interactions using rat models to elucidate Neuromedin S-mediated physiological processes

Research on metabolic disorders, obesity, and sleep-wake cycle disturbances by targeting the Neuromedin S-NMU receptor axis

3.CLINICAL EFFICACY OF PRODUCT

In NMU receptor functional assays, it serves as a reliable positive control to evaluate the efficacy and potency of NMU-targeted drug candidates for metabolic and neurological disorders

In rat models of circadian rhythm disorders and obesity, it aids in elucidating the role of the Neuromedin S-NMU axis, supporting the development of novel therapeutics for sleep disorders and weight management

It facilitates the characterization of NMU receptor expression and signaling in central and peripheral tissues, providing insights for identifying therapeutic targets in stress-related disorders and water balance dysregulation

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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