Neuropeptide Y (13-36), human CAS NO.122341-40-6

<p>Neuropeptide Y (13-36), human is a C-terminal fragment of human NPY (residues 13-36) with C-terminal amidation, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains high affinity for NPY receptors with strong preference for the Y₂ subtype, serving as a key tool for dissecting Y₂-mediated signaling pathways. It is widely used in receptor binding assay…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (13-36), human
CAS NO.	122341-40-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C134H207N41O36S
Molecular Weight	3000.46g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1 % v/v), or phosphate-buffered saline (PBS). For best results, first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution, then dilute with assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is the C-terminal fragment (residues 13-36) of human Neuropeptide Y. It retains significant, though often reduced compared to full-length NPY, affinity for NPY receptors, with a preference for the Y₂ receptor subtype. It acts as a partial agonist or antagonist depending on the assay system, and is commonly used to study Y₂ receptor-specific functions. Activity should be validated in relevant receptor binding or functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Neuropeptide Y (13-36) functions as a Y₂ receptor-preferring agonist that binds with high affinity to NPY Y₂ receptors, coupling to Gi/o proteins to inhibit adenylate cyclase and reduce intracellular cAMP levels. This signaling cascade leads to activation of inwardly rectifying potassium channels and inhibition of voltage-gated calcium channels, resulting in presynaptic inhibition of neurotransmitter release (particularly glutamate and GABA). The peptide's mechanism produces decreased neuronal excitability, modulation of synaptic plasticity, and physiological effects on feeding behavior, anxiety-like responses, and cognitive functions, making it a selective probe for Y₂ receptor-specific pathways.

2.PRODUCT INDICATIONS

This human NPY fragment is indicated exclusively for research applications focused on Y₂ receptor pharmacology and presynaptic modulation studies. It is employed in Y₂-selective receptor binding and autoradiography assays, functional studies measuring cAMP inhibition and neurotransmitter release, appetite and feeding behavior research with emphasis on Y₂-mediated satiety effects, anxiety and stress response models, memory and synaptic plasticity investigations, and validation of Y₂ receptor expression in various tissues. The product serves as a reference agonist for screening Y₂-selective antagonists and studying the role of Y₂ receptors in obesity, anxiety disorders, and cognitive impairment. It is not intended for diagnostic, therapeutic, or clinical use.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuropeptide Y (13-36), human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of Y₂ receptor biology and may inform the development of future therapeutic agents targeting Y₂ receptors for obesity, anxiety, or cognitive disorders, its utility remains confined to preclinical research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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