Neuropeptide Y (13-36) (porcine) CAS NO.113662-54-7

<p>Neuropeptide Y (13-36) (porcine) (CAS NO. 113662-54-7) is a synthetic, 24-amino acid C-terminal fragment of porcine neuropeptide Y (NPY). This research-grade peptide represents a major enzymatically cleaved metabolite of the full-length hormone. It lacks the N-terminal region critical for Y1 receptor activation but retains the core structure required for binding to other NPY receptor subtypes, serving as an essen…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuropeptide Y (13-36) (porcine)
CAS NO.	113662-54-7
Appearance	Lyophilized white to off-white powder
Molecular Formula	C135H209N41O36
Molecular Weight	2982.4/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO; gentle sonication may aid full dissolution
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for neuropeptide Y (NPY) Y₁ and Y₅ receptors
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment acts primarily as a selective agonist for the neuropeptide Y Y2 receptor (NPY Y2R). Due to the absence of the N-terminal Tyr¹-Pro²-Ser³-Lys⁴ motif, it has very low affinity for the Y1 receptor. Its binding to the presynaptic Y2 receptor activates the inhibitory Gi/o protein pathway, leading to inhibition of adenylate cyclase and a decrease in intracellular cyclic AMP (cAMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for focused research in neuropharmacology, cardiovascular biology, and metabolism where selective Y2 receptor activation is required. Key applications include: studying the physiological roles of presynaptic Y2 receptors in the central and peripheral nervous systems, investigating Y2-mediated effects on anxiety, memory, and feeding behavior, exploring its vasodilatory and sympatholytic actions in cardiovascular research, and serving as a standard selective Y2 receptor agonist in competitive binding assays and functional studies to characterize novel Y2 receptor ligands.

3.CLINICAL EFFICACY OF PRODUCT

Neuropeptide Y (13-36) is a research compound, not a clinical drug. Its efficacy is defined by its critical role as a selective pharmacological tool. Research utilizing this fragment has been fundamental in mapping the distinct functions of the Y2 receptor, separate from the Y1 receptor. The understanding gained from such studies has validated the Y2 receptor as a promising therapeutic target.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.