[D-Tyr27,36, D-Thr32]-Neuropeptide Y, human

<p>[D-Tyr²⁷,³⁶, D-Thr³²]-Neuropeptide Y (human) is a synthetic, extensively modified analog of human neuropeptide Y (NPY). This advanced research-grade peptide incorporates D-amino acid substitutions at three strategic positions (tyrosine at 27 and 36, threonine at 32). These modifications are engineered to confer exceptional resistance to proteolytic degradation, significantly extending its biological half-life, wh…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Tyr27,36, D-Thr32]-Neuropeptide Y, human
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C189H285N55O57S
Molecular Weight	4271.8/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, dilute acetic acid (0.1% v/v) and DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective neuropeptide Y (NPY) Y₂ receptor agonist
Storage Conditions	Lyophilized powder: Long-term storage at -20°C to -80°C (stable for 24 months at -80°C, 12 months at -20°C)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This multi-D-amino acid analog functions as a potent agonist for NPY receptors, with its receptor selectivity profile influenced by the specific D-substitutions. The incorporation of D-amino acids makes it highly resistant to cleavage by most endogenous proteases, allowing for sustained receptor activation in experimental settings. It primarily targets Y1, Y2, and Y5 receptor subtypes, activating the canonical Gi/o protein pathway upon binding.

2.PRODUCT INDICATIONS

This product is indicated for sophisticated, long-duration research in neuropharmacology and cardiovascular physiology. Key applications include: investigating the chronic effects of NPY signaling in models of obesity, hypertension, and anxiety disorders; serving as a stable, long-lasting agonist in extended functional assays and in vivo studies; exploring the impact of multiple D-amino acid substitutions on peptide stability, receptor affinity, and in vivo pharmacokinetics; and as a lead compound in the design of therapeutic NPY analogs with enhanced metabolic stability.

3.CLINICAL EFFICACY OF PRODUCT

[D-Tyr²⁷,³⁶, D-Thr³²]-NPY is a cutting-edge research tool for peptide engineering, not a clinical drug. Its "efficacy" is demonstrated by its utility as a proof-of-concept molecule showcasing a successful strategy to overcome the primary limitation of natural peptides: rapid degradation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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