Obestatin, human CAS NO.1081110-72-6

<p>Obestatin, human is a 23-amino acid peptide hormone derived from the C-terminal region of the ghrelin preproprotein, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide is amidated at the C-terminus to enhance stability and is characterized by its role in appetite regulation and energy homeostasis. It is primarily used in studies investigating the ghrelin-o…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Obestatin, human
CAS NO.	1081110-72-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C16H176N32O33
Molecular Weight	2546.89 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Obestatin is a peptide hormone derived from the ghrelin gene, initially reported to oppose ghrelin's effects on food intake and gastric motility, primarily through binding to the GPR39 receptor. It is involved in regulating appetite, energy balance, and gastrointestinal functions. Bioactivity can be validated in in vitrocell‑based assays (e.g., cAMP accumulation or calcium flux in GPR39‑expressing cells) or in vivofeeding models.
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Obestatin functions by binding to the G protein-coupled receptor GPR39, activating signaling pathways that involve Gq/11 proteins, leading to increased intracellular calcium mobilization and activation of phospholipase C. This signaling cascade results in the inhibition of food intake, suppression of gastric emptying, and modulation of insulin secretion and glucose metabolism. Unlike ghrelin, which stimulates appetite, obestatin exerts anorexigenic effects by opposing ghrelin's actions on hypothalamic neurons and gastrointestinal function. The peptide's amidated C-terminus is critical for receptor binding and biological activity, contributing to its stability and efficacy in experimental systems.

2.PRODUCT INDICATIONS

Obestatin, human is indicated exclusively for research applications focused on appetite regulation, energy balance, and metabolic function. It is employed in in vitrostudies using cell lines expressing GPR39 to assess calcium flux, cAMP accumulation, and other signaling pathways. The peptide is also used in in vivomodels to investigate feeding behavior, body weight regulation, gastric motility, and glucose homeostasis. Additionally, it serves as a reference standard in receptor binding assays, autoradiography, and immunohistochemistry to localize obestatin binding sites in tissues. The product is not intended for diagnostic, therapeutic, or clinical use and is strictly for research purposes.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Obestatin, human has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to the fundamental understanding of appetite regulation and metabolic disorders and may inform the development of future therapeutic strategies targeting the ghrelin-obestatin axis, its utility remains confined to preclinical research. Any clinical translation would require the development of distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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