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Chemicals
Neurotensin (8-13) CAS NO.60482-95-3
<p>Neurotensin (8-13) (CAS NO. 60482-95-3) is a synthetic hexapeptide representing the C-terminal active core fragment of the full-length neurotensin (NT) neuropeptide. This high-purity, research-grade fragment (Arg-Arg-Pro-Tyr-Ile-Leu) retains the full biological activity of native NT but offers enhanced metabolic stability and potency. It serves as a fundamental and potent agonist for neurotensin receptor studies.…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neurotensin (8-13) |
| CAS NO. | 60482-95-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C38H64N12O8 |
| Molecular Weight | 817.01/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (up to 10 mg/mL), dilute acetic acid, or DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent agonist of the neurotensin receptor (NTS1 and NTS2). |
| Storage Conditions | Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide acts as a potent agonist for neurotensin receptors, primarily NTS1 and NTS2. The C-terminal hexapeptide sequence constitutes the minimal fragment required for high-affinity receptor binding and activation. Upon binding, it triggers Gq protein-mediated signaling, leading to phospholipase C (PLC) activation. This results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG), causing intracellular calcium mobilization and protein kinase C (PKC) activation.
2.PRODUCT INDICATIONS
This product is indicated for a wide range of in vitro and in vivo research in neuroscience, pharmacology, and oncology. Key applications include: studying neurotensin receptor pharmacology and downstream signaling pathways, investigating its roles in pain modulation, body temperature regulation, and antipsychotic-like effects, exploring its mitogenic and proliferative effects in cancer models (e.g., pancreatic, colon), and serving as a standard high-potency agonist in receptor binding assays and functional studies (e.g., calcium mobilization).
3.CLINICAL EFFICACY OF PRODUCT
Neurotensin (8-13) is a potent research tool and not a clinical drug. Its "efficacy" is defined by its critical role in validating the neurotensin system as a therapeutic target. Preclinical research using this fragment has been pivotal in demonstrating NT's involvement in pain pathways, schizophrenia-related behaviors, and cancer cell proliferation. .
4.DELIVERY & SHIPPING
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Global Technology Co., Ltd.
