[Trp11]-Neurotensin

<p>[Trp¹¹]-Neurotensin is a premium synthetic neurotensin analog with a defined molecular formula (C₈₀H₁₂₂N₂₂O₁₉) and molecular weight (1696 g/mol). As a professional [Trp¹¹]-Neurotensin supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and enhanced metabolic stability, ensuring selective NTS1/NTS2 agonist activity. Tailored for neuroscience, pharmacology, and gastrointestinal resea…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Trp11]-Neurotensin
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₈₀H₁₂₂N₂₂O₁₉
Molecular Weight	1696 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in distilled water, PBS buffer (pH 7.2–7.4), and DMSO; slightly soluble in methanol and ethanol.
Endotoxin	< 1.0 EU/mg
Biological Activity	Selective agonist for neurotensin receptors (NTS1, NTS2); modulates dopamine release, nociception, gastrointestinal motility, and central nervous system signaling; exhibits modified binding kinetics and metabolic stability relative to native neurotensin
Storage Conditions	Ambient or blue ice shipping (non-hazardous for international transport)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Trp¹¹]-Neurotensin exerts its biological effects through high-affinity and selective binding to neurotensin receptors NTS1 and NTS2—G-protein-coupled receptors (GPCRs) widely expressed in the CNS (striatum, hypothalamus), gastrointestinal tract, and peripheral tissues. The Trp substitution at position 11 optimizes the peptide’s conformational structure, enhancing its resistance to enzymatic degradation and altering binding kinetics relative to native neurotensin, while maintaining specificity for NTS1 and NTS2.

2.PRODUCT INDICATIONS

Neurotensin receptor research: Investigation of NTS1/NTS2 structure-function relationships, serving as a standard ligand for receptor activation assays, agonist/antagonist screening, and binding kinetic analysis.

Neuroscience research: Study of dopamine release regulation, nociception, and CNS signaling pathways, leveraging the analog’s improved stability for long-term in vitro and in vivo assays.

Gastrointestinal research: Evaluation of the peptide’s role in modulating gastrointestinal motility, supporting studies on gut-brain axis interactions and gastrointestinal disorders.

3.CLINICAL EFFICACY OF PRODUCT

[Trp¹¹]-Neurotensin is widely utilized in preclinical research, with proven efficacy in in vitro and in vivo models. In neuronal cell assays, it exhibits potent NTS1/NTS2 activation, effectively modulating dopamine release and neuronal excitability with prolonged activity due to its enhanced metabolic stability—outperforming native neurotensin in long-term experiments.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.