[D-Tyr¹¹]-Neurotensin

<p>[D-Tyr¹¹]-Neurotensin is a premium synthetic neurotensin analog with a defined molecular formula (C₇₈H₁₂₁N₂₁O₂₀) and molecular weight (1673 g/mol). As a professional [D-Tyr¹¹]-Neurotensin supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and enhanced metabolic stability via D-Tyr substitution, ensuring potent NTS1/NTS2 agonist activity. Tailored for neuroscience, neuropharmacolog…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Tyr¹¹]-Neurotensin
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₇₈H₁₂₁N₂₁O₂₀
Molecular Weight	1673g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in distilled water (≥ 2 mg/mL), PBS buffer (pH 7.2–7.4, ≥ 1.5 mg/mL), and DMSO (≥ 15 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of neurotensin receptors NTS1 and NTS2; modulates glutamatergic neurotransmission in ventral midbrain neurons; induces conditioned place preference (CPP) via NTS1 receptor activation; regulates dopamine signaling and limbic neurotransmission; exhibits enhanced metabolic stability compared to native neurotensin
Storage Conditions	Store at -20°C (desiccated, airtight, light-protected container) for 2–3 years
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[D-Tyr¹¹]-Neurotensin exerts its biological effects through high-affinity binding to both NTS1 and NTS2 neurotensin receptors—G-protein-coupled receptors (GPCRs) widely expressed in the central nervous system (ventral midbrain, limbic system, spinal cord) and peripheral tissues. The D-Tyr substitution at position 11 is the core structural modification that enhances the peptide’s resistance to endogenous peptidases, prolonging its half-life and sustaining biological activity compared to native neurotensin, while maintaining high receptor selectivity.

2.PRODUCT INDICATIONS

NTS receptor research: Investigation of NTS1/NTS2 structure-function relationships, serving as a standard ligand for receptor activation assays, agonist/antagonist screening, and binding kinetic analysis.

Neuroscience research: Study of dopamine signaling, glutamatergic neurotransmission, and limbic system function, leveraging the analog’s enhanced stability for long-term neurophysiology assays.

Pharmacology research: Development and validation of NTS receptor-targeted therapeutics for neurological disorders, reward-related behaviors, and pain management.

3.CLINICAL EFFICACY OF PRODUCT

[D-Tyr¹¹]-Neurotensin is widely utilized in preclinical neuroscience research, with proven efficacy in in vitro and in vivo rodent models. In ventral midbrain neuronal cell assays, it exhibits potent NTS1/NTS2 activation, effectively modulating glutamatergic and dopaminergic neurotransmission with sustained activity due to its D-Tyr-enhanced metabolic stability—outperforming native neurotensin in long-duration experiments.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.