VIP, guinea pig CAS NO.96886-24-7

<div class="ybc-p">VIP, guinea pig (CAS NO. 96886-24-7) is a synthetic, 28-amino acid peptide representing the vasoactive intestinal peptide (VIP) isoform specific to the guinea pig (Cavia porcellus). This high-purity, species-specific neuropeptide is a potent endogenous agonist for VPAC1 and VPAC2 receptors. It serves as an essential research tool for studying VIP-mediated physiology and pharma…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	VIP, guinea pig
CAS NO.	96886-24-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C147H239N43O42S2
Molecular Weight	3344.93/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.1M HCl
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent vasodilator and neurotransmitter; binds to VPAC1 and VPAC2 receptors, regulating smooth muscle relaxation, vasodilation, and immune function.
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its broad physiological effects by binding to and activating two class B G protein-coupled receptors, VPAC1 and VPAC2, with high affinity. Receptor activation primarily stimulates the Gs protein pathway, leading to activation of adenylate cyclase, a significant increase in intracellular cyclic AMP (cAMP) levels, and subsequent activation of protein kinase A (PKA).

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research using guinea pig tissues or animal models. Key applications include: studying VIP-mediated smooth muscle relaxation in respiratory (trachea, bronchi) and gastrointestinal tracts; investigating its immunomodulatory and anti-inflammatory effects; exploring its role as a neuroprotective factor and neurotransmitter/neuromodulator in the central and peripheral nervous systems; and serving as the species-specific reference agonist for receptor binding, cAMP accumulation, and functional relaxation assays in guinea pig-based experiments.

3.CLINICAL EFFICACY OF PRODUCT

VIP, guinea pig itself is not a human therapeutic but is a cornerstone research reagent. Its "efficacy" is proven in preclinical guinea pig models, which are gold standards for studying human-like airway and smooth muscle physiology. Research using this species-specific peptide has been fundamental in elucidating VIP's role as a potent bronchodilator and anti-inflammatory agent in the lungs, directly contributing to the validation of the VIP/VPAC receptor pathway as a therapeutic target for respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD).

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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