Xenopsin CAS NO.51827-01-1

<p>Xenopsin (CAS NO. 51827-01-1) is a synthetic, 8-amino acid neuropeptide originally isolated from the skin of the African clawed frog, <em>Xenopus laevis</em>. This research-grade peptide is a member of the physalaemin/tachykinin peptide family and shares structural and functional similarities with mammalian neurokinins like substance P. It serves as a valuable tool in comparative neurobiology and pharmacology for…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Xenopsin
CAS NO.	51827-01-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C47H73N13O10
Molecular Weight	980.19/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥25 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Exhibits potent hypotensive and smooth muscle-stimulating activity; acts as a tachykinin-like peptide with affinity for neurokinin receptors
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Xenopsin exerts its biological effects by acting as an agonist for tachykinin receptors, primarily the neurokinin 1 (NK1) receptor, similar to substance P. Upon binding, it activates the Gq protein-coupled signaling pathway, leading to phospholipase C (PLC) activation, hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG), and subsequent intracellular calcium mobilization.

2.PRODUCT INDICATIONS

This product is indicated for research in comparative physiology, neuropharmacology, and smooth muscle biology. Key applications include: studying the evolutionary biology of tachykinin peptides and their receptors across species; investigating its potent stimulatory effects on gastrointestinal and smooth muscle contraction in bioassays; exploring its role in amphibian skin secretion physiology; and serving as a unique, non-mammalian reference agonist in studies of NK1 receptor pharmacology and function, particularly for cross-species receptor characterization.

3.CLINICAL EFFICACY OF PRODUCT

Xenopsin is not a clinical therapeutic but a fundamental research peptide from a non-mammalian source. Its efficacy lies in its significant role as a molecular tool in basic science. By studying xenopsin, researchers gain insights into the structure, function, and evolution of the tachykinin peptide family. This comparative approach helps identify conserved receptor-binding motifs and functional domains, which can inform the rational design of novel tachykinin receptor ligands. Furthermore, research on amphibian skin peptides like xenopsin has historically been a rich source for discovering novel bioactive compounds with potential therapeutic leads.

4.DELIVERY & SHIPPING

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