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Chemicals
Adrenorphin CAS NO.88377-68-8
<p>Adrenorphin (CAS NO. 88377-68-8) is a synthetic, amidated octapeptide (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH₂) derived from the proenkephalin A precursor. This research-grade opioid peptide is a potent endogenous agonist for μ-opioid and δ-opioid receptors. It serves as a crucial tool for studying opioidergic neurotransmission, pain modulation, and stress-related physiological responses.</p>
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Adrenorphin |
| CAS NO. | 88377-68-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C44H69N15O9S |
| Molecular Weight | 984.2/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥25 mg/mL), dilute acetic acid, or DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Selective opioid receptor agonist (high affinity for μ and κ-opioid receptors); exhibits potent analgesic activity, modulates stress and pain signaling pathways |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Adrenorphin exerts its biological effects by binding with high affinity to μ-opioid (MOP) and δ-opioid (DOP) receptors in the central and peripheral nervous systems. Upon binding, it activates inhibitory Gi/o proteins, leading to the inhibition of adenylate cyclase, reduced cAMP production, and subsequent modulation of ion channels (e.g., opening of potassium channels, closing of calcium channels).
2.PRODUCT INDICATIONS
This product is indicated for in vitro and in vivo research in neuropharmacology and pain biology. Key applications include: studying the pharmacology of μ- and δ-opioid receptors and their downstream signaling pathways; investigating endogenous opioid systems in pain modulation and stress responses; exploring adrenorphin's role in addiction, reward, and emotional behavior; and serving as a potent reference agonist in opioid receptor binding assays and functional studies for screening and characterizing novel opioid ligands.
3.CLINICAL EFFICACY OF PRODUCT
Adrenorphin is a research tool and not used directly in clinical therapy. However, its "efficacy" as a potent endogenous opioid peptide has made it a valuable probe for understanding the opioid system. Research using adrenorphin has contributed to mapping the physiological roles of opioid receptors, particularly in pain and stress pathways. This foundational knowledge is critical for the ongoing development of safer and more effective opioid analgesics, as well as for understanding the mechanisms underlying opioid tolerance, dependence, and addiction, which are major challenges in pain management.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
