P75-TNFR Fragment

<p>P75-TNFR Fragment is a purified, research-grade recombinant protein representing a key functional domain of the human p75 (75 kDa) Tumor Necrosis Factor Receptor (also known as TNFR2, CD120b, or TNFRSF1B). This high-purity fragment corresponds to a soluble, ligand-binding portion of the extracellular domain, specifically engineered to bind with high affinity to its primary ligand, Tumor Necrosis Factor-alpha (TNF…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	P75-TNFR Fragment
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₉₄H₄₆₅N₈₁O₉₁S₃
Molecular Weight	~30–35 kDa (extracellular domain fragment); ~6.8 kDa (peptide fragment)
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, 0.1% TFA, or PBS (pH 7.2–7.4); reconstitute to 0.5–5 mg/mL
Endotoxin	≤1.0 EU/mg
Biological Activity	Binds to TNF-α and TNF-β with high affinity; inhibits TNF-mediated cellular responses. Activity is typically measured via competitive binding assay (IC₅₀: 0.05–0.5 μg/mL)
Storage Conditions	Lyophilized powder: -20°C to -80°C for long-term storage; avoid repeated freeze-thaw. Reconstituted solution: 4°C for up to 2 weeks, or -20°C with 0.1% HSA/BSA for 3–6 months
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This fragment acts as a selective decoy receptor or neutralizing agent within the TNF signaling system. By mimicking a part of the native TNFR2 extracellular structure, it binds specifically to soluble TNF-α and its transmembrane form (tmTNF-α), sequestering the cytokine and preventing its interaction with endogenous, cell-surface TNFR1 and TNFR2 receptors. This competitive inhibition specifically blocks the signaling cascades initiated through TNFR2 binding, which are associated with distinct biological outcomes such as cell proliferation, survival, and immunoregulation, contrasting with the pro-apoptotic signals often triggered by TNFR1.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in immunology, neurobiology, and oncology, where the specific role of TNFR2 signaling is of interest. Key applications include: investigating the unique functions of TNF-α/TNFR2 signaling in T-regulatory cell (Treg) expansion, neuronal survival, and tissue regeneration; selectively neutralizing TNF-α effects mediated via TNFR2 to dissect its contribution from TNFR1-mediated effects in complex biological systems; as a tool for studying the role of tmTNF-α in reverse signaling; and in the development of assays to probe TNFR2-specific interactions and functions.

3.CLINICAL EFFICACY OF PRODUCT

The P75-TNFR Fragment is a research protein, but its therapeutic concept is highly significant. Research with this and similar fragments has illuminated the dichotomy of TNF signaling and validated TNFR2 as a promising therapeutic target. While TNFR1 inhibition is the basis for drugs like etanercept, selective TNFR2 agonism is now being explored as a novel strategy to promote tissue protection, enhance Treg function, and combat autoimmunity and neurodegeneration without the immunosuppressive risks of broad TNF blockade. This fragment is thus a critical tool for the preclinical development of next-generation, pathway-specific TNF modulators.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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