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Chemicals
Hexapeptide-2 CAS NO.87616-84-0
<p><strong>Hexapeptide-2</strong> (CAS NO. 87616-84-0) is a synthetic, biomimetic hexapeptide engineered for targeted cosmetic and dermatological applications. This specific sequence is designed to modulate skin pigmentation processes, functioning as an effective active ingredient for brightening formulations. It works by interfering with key steps in melanogenesis (melanin production), helping to reduce the appeara…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Hexapeptide-2 |
| CAS NO. | 87616-84-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C46H56N12O6 |
| Molecular Weight | 873.01 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥30 mg/mL), soluble in dilute aqueous buffers; slightly soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Acts as α-MSH antagonist to inhibit melanin synthesis and hyperpigmentation; evens skin tone, reduces dark spots and UV-induced pigmentation; also promotes growth hormone release (GHRP-6 activity) and supports skin anti-aging. |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark, sealed container; avoid repeated freeze-thaw cycles; short-term (≤1 week) at 2–8°C. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Hexapeptide-2 operates through a multi-targeted inhibitory mechanism within the melanogenesis pathway:
- Competitive Inhibition of Tyrosinase: The peptide acts as a substrate mimic, competitively binding to the active site of the enzyme tyrosinase. This binding prevents the enzyme from processing its natural substrate (L-tyrosine), thereby directly inhibiting the rate-limiting first step in melanin synthesis.
- Interference with Melanosome Transfer: Evidence suggests Hexapeptide-2 may also help reduce the transfer of melanin-containing melanosomes from melanocytes to surrounding keratinocytes (skin cells). This limits the visible pigmentation on the skin's surface.
- Downregulation of Pigmentation Signals: It may help modulate the cellular signaling (e.g., from α-MSH or UV exposure) that triggers overproduction of melanin.
This combined action helps to prevent new pigment formation and disperse existing pigmentation.
2.PRODUCT INDICATIONS
This product is indicated for cosmetic science and the formulation of advanced skin-brightening and pigmentation-correcting products. Key applications include:
- As a core active in skin-lightening serums, creams, and spot treatments for melasma, solar lentigines (sun spots), and post-inflammatory hyperpigmentation (PIH).
- In products designed to even overall skin tone and reduce the appearance of freckles and age spots.
- For preventative brightening skincare to inhibit UV-induced or hormonal pigmentation.
- As an ingredient in professional treatments for correcting hyperpigmentation and achieving a luminous glow.
- In formulations targeting a bright, uniform complexion as part of anti-aging regimens.
3.CLINICAL EFFICACY OF PRODUCT
Hexapeptide-2 is supported by in vitro data demonstrating its tyrosinase-inhibitory activity and clinical evaluations in finished cosmetic products. Studies typically show:
- A significant reduction in the melanin index and visible lightening of hyperpigmented areas.
- Effective fading of dark spots and improved skin tone uniformity with regular use.
- A good safety and tolerability profile, often making it suitable for sensitive skin types seeking alternatives to stronger depigmenting agents.
- Enhanced skin radiance and clarity, contributing to a more youthful and healthy-looking appearance.
Its efficacy validates its role as a potent and targeted ingredient for managing skin discoloration.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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Global Technology Co., Ltd.
