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Chemicals
Decapeptide-12 CAS NO.137665-91-9
<p>Decapeptide-12 is a synthetic ten-amino acid peptide designed for advanced cosmetic applications, with a primary focus on <strong>skin brightening and pigmentation correction</strong>. This biomimetic peptide is engineered to interfere with the melanogenesis (melanin production) pathway, effectively targeting hyperpigmentation, dark spots, and uneven skin tone to promote a more radiant and uniform complexion.<br/…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Decapeptide-12 |
| CAS NO. | 137665-91-9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₆₅H₉₀N₁₈O₁₇ |
| Molecular Weight | 1395.52g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water; soluble in dilute acids or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Competitive tyrosinase inhibitor (mushroom tyrosinase IC₅₀=40 μM; human tyrosinase inhibition 35% at 100 μM); binds to tyrosinase C-terminal (Kd=61.1 μM); reduces melanin production; used in skin brightening & hyperpigmentation treatments |
| Storage Conditions | Store at -20°C to -8°C (long-term); 4°C for short-term (≤1 week); avoid repeated freeze-thaw cycles; protect from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Decapeptide-12 operates through a multi-targeted inhibitory mechanism within the melanogenesis pathway:
- Tyrosinase Inhibition: It acts as a competitive inhibitor of the enzyme tyrosinase, binding to its active site and blocking its ability to convert L-tyrosine to melanin precursors like DOPA and dopaquinone.
- Interference with Melanosome Transfer: The peptide may also inhibit the transfer of mature melanin-containing melanosomes from melanocytes to surrounding keratinocytes. This prevents the visible pigmentation from reaching the skin's surface.
- Anti-Inflammatory Action: It possesses properties that help reduce skin inflammation, which can be a trigger for post-inflammatory hyperpigmentation (PIH).
By combining these actions, Decapeptide-12 effectively reduces both the production and distribution of melanin in the skin.
2.PRODUCT INDICATIONS
This product is indicated for cosmetic science and the formulation of high-performance skin-brightening and pigment-correcting products. Key applications include:
- As a key active in brightening serums, creams, and spot treatments for conditions like melasma, sun spots (solar lentigines), and post-inflammatory hyperpigmentation (PIH).
- In formulations designed to even overall skin tone and reduce the appearance of age spots and freckles.
- For preventative skincare regimens aimed at inhibiting UV-induced or hormonally-triggered pigmentation.
- As a component in professional treatments for correcting hyperpigmentation and achieving a luminous glow.
- In comprehensive anti-aging products that address photoaging concerns like uneven pigmentation and dullness.
3.CLINICAL EFFICACY OF PRODUCT
Decapeptide-12 is supported by in vitro data demonstrating its tyrosinase-inhibitory activity and by clinical evaluations in cosmetic formulations. Studies typically show:
- A significant reduction in the melanin index and visible lightening of hyperpigmented areas.
- Effective fading of dark spots and improvement in overall skin tone uniformity with regular use.
- A good safety and tolerability profile, often making it suitable for sensitive skin types as an alternative to more traditional, potentially irritating brightening agents.
- Enhanced skin radiance, clarity, and brightness, contributing to a more youthful and healthy-looking appearance.
Its efficacy validates its role as a potent and versatile ingredient for managing various forms of skin discoloration.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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Global Technology Co., Ltd.
